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夫西地酸

夫西地酸用途

Fusidic acid (Fusidate) 是一种抑菌抗生素。

夫西地酸名称

[ CAS 号 ]:
6990-06-3

[ 中文名 ]:
夫西地酸

[ 英文名 ]:
fusidic acid

[中文别名 ]:

褐霉酸

[英文别名 ]:

Fucidic acid
Fusidate sodium
EINECS 230-256-0
fusidic acid
Fusidin
FUCIDIN
Fusidate
Ramycin
fusdic acid
Fucithalmic

夫西地酸生物活性

[ 描述 ]:

Fusidic acid (Fusidate) 是一种抑菌抗生素。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[ 靶点 ]

Bacterial[1][2][3]

[参考文献]

[1]. Falagas ME, et al. Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther. 2008 Oct;6(5):593-600.

[2]. Leclercq R, et al. In vitro activity of fusidic acid against streptococci isolated from skin and soft tissue infections. J Antimicrob Chemother. 2000 Jan;45(1):27-9.

[3]. Spelman D, et al. Fusidic acid in skin and soft tissue infections. Int J Antimicrob Agents. 1999 Aug;12 Suppl 2:S59-66.

夫西地酸物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
635.6±55.0 °C at 760 mmHg

[ 熔点 ]:
190-192ºC

[ 分子式 ]:
C₃₁H₄₈O₆

[ 分子量 ]:
516.709

[ 闪点 ]:
197.7±25.0 °C

[ 精确质量 ]:
516.345093

[ PSA ]:
104.06000

[ LogP ]:
6.41

[ 外观性状 ]:
白色固体

[ 蒸汽压 ]:
0.0±4.2 mmHg at 25°C

[ 折射率 ]:
1.558

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
水溶性：实际上不溶；可溶于：氯仿,醇,丙酮,二噁烷；极微溶：乙醚

夫西地酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RC1350000

CHEMICAL NAME :: 29-Nordammara-17(20),24-dien-21-oic acid, 16-(acetyloxy)-3,11-dihydroxy-, (3-alpha,4-alpha, 8-alpha,9-beta,11-alpha,13-alpha,14-beta,16-beta,17Z) -

CAS REGISTRY NUMBER :: 6990-06-3

LAST UPDATED :: 199603

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C31-H48-O6

MOLECULAR WEIGHT :: 516.79

WISWESSER LINE NOTATION :: L E5 B666 FYTJ A CQ FUYVQ3UY GOV1 I J N OQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 420 mg/kg/2W-I

TOXIC EFFECTS :: Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 165 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 15 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Insect - Drosophila melanogaster Cells - not otherwise specified

DOSE/DURATION :: 100 mg/L

REFERENCE :: CLDFAT Cell Differentiation. (Limerick, Ireland) V.1-24, 1972-88. Volume(issue)/page/year: 2,97,1973

夫西地酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
RC1350000

[ 海关编码 ]:
2942000000

夫西地酸海关

[ 海关编码 ]: 2942000000

夫西地酸文献

Antibiotic exposure in a low-income country: screening urine samples for presence of antibiotics and antibiotic resistance in coagulase negative staphylococcal contaminants.

PLoS ONE 9(12) , e113055, (2014)

Development of antimicrobial resistance has been assigned to excess and misuse of antimicrobial agents. Staphylococci are part of the normal flora but are also potential pathogens that have become ess...

Multiple roles for Enterococcus faecalis glycosyltransferases in biofilm-associated antibiotic resistance, cell envelope integrity, and conjugative transfer.

Antimicrob. Agents Chemother. 59 , 4094-105, (2015)

The emergence of multidrug-resistant bacteria and the limited availability of new antibiotics are of increasing clinical concern. A compounding factor is the ability of microorganisms to form biofilms...

Enterococcus faecalis 6-phosphogluconolactonase is required for both commensal and pathogenic interactions with Manduca sexta.

Infect. Immun. 83(1) , 396-404, (2014)

Enterococcus faecalis is a commensal and pathogen of humans and insects. In Manduca sexta, E. faecalis is an infrequent member of the commensal gut community, but its translocation to the hemocoel res...

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