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琥珀半醛

琥珀半醛用途

Succinaldehydic acid 是 GABA 的代谢物。

琥珀半醛名称

[ CAS 号 ]:
692-29-5

[ 中文名 ]:
琥珀半醛

[ 英文名 ]:
Succinaldehydic acid

[英文别名 ]:

琥珀半醛生物活性

[ 描述 ]:

Succinaldehydic acid 是 GABA 的代谢物。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他
研究领域 >> 其他

[体外研究]

琥珀酸(琥珀酸半醛)是GABA的分解代谢物,其通过GABA分流在线粒体基质中分解代谢,包括通过GABA转氨酶(GABA-T)和琥珀酸半醛脱氢酶的协同作用转化为琥珀酸,然后氧化成琥珀酸。 (SSADH),分别为[1]。

[参考文献]

[1]. Ravasz D, et al. Catabolism of GABA, succinic semialdehyde or gamma-hydroxybutyrate through the GABA shunt impair mitochondrial substrate-level phosphorylation. Neurochem Int. 2017 Oct;109:41-53.


[相关活性小分子]

磺丁基-β-环糊精钠盐 | 环孢霉素A | 2-(3,6-二乙酰氧基-2,7-二氯-9H-氧杂蒽-9-基)苯甲酸 | 1-甲基-4-苯基-1,2,3,6-四氢吡啶盐酸盐 | GW4869 | 乙莫克舍 | (2R,2'R,3R,3'R,4S,4'S,5R,5'R,6S,6'S)-6,6'-硫代双(4-(4-(3-氟苯基)-1H-1,-1H-1,2,3-三唑-1-基)-2-(羟甲基)四氢-2H-吡喃-3,5-二醇) | Mitoquinone甲磺酸盐 | GSK2795039 | CBIC2 | BAPTA-AM | AP20187 | GKT137831 | D-(-)-荧光素 | 单响尾蛇毒蛋白

琥珀半醛物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
248.6±23.0 °C at 760 mmHg

[ 分子式 ]:
C4H6O3

[ 分子量 ]:
102.089

[ 闪点 ]:
118.4±19.1 °C

[ 精确质量 ]:
102.031693

[ PSA ]:
54.37000

[ LogP ]:
-0.35

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.430

琥珀半醛毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WM3380000
CHEMICAL NAME :
Succinaldehydic acid
CAS REGISTRY NUMBER :
692-29-5
BEILSTEIN REFERENCE NO. :
1745187
LAST UPDATED :
199712
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C4-H6-O3
MOLECULAR WEIGHT :
102.10
WISWESSER LINE NOTATION :
VH2VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #3296M
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1900 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 3,697,1969
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #3296M
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #3296M

琥珀半醛安全信息

[ 海关编码 ]:
2918300090

琥珀半醛合成路线

详细合成路线

琥珀半醛上下游产品

琥珀半醛上游产品

琥珀半醛下游产品

琥珀半醛海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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相关化合物

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标题：琥珀半醛_用途_密度_沸点_琥珀半醛CAS号【692-29-5】_化源网 地址：https://www.chemsrc.com/amp/cas/692-29-5_1028628.html