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2(5H)-呋喃酮

2(5H)-呋喃酮用途

2(5H)-Furanone 是一种内源性代谢产物。

2(5H)-呋喃酮名称

[ CAS 号 ]:
497-23-4

[ 中文名 ]:
2(5H)-呋喃酮

[ 英文名 ]:
2(5H)-Furanone

[中文别名 ]:

[英文别名 ]:

5-Hydrofuran-2-one
Furan-2(5H)-one
4-Hydroxycrotonic acid γ-lactone
2H-furan-5-one
2-Butenoic acid-γ-lactone
EINECS 207-839-3
T5OV EHJ
2-Butenoic acid γ-lactone
2(5H)-Furanone
MFCD00005376

2(5H)-呋喃酮生物活性

[ 描述 ]:

2(5H)-Furanone 是一种内源性代谢产物。

[ 相关类别 ]:

研究领域 >> 代谢疾病

2(5H)-呋喃酮物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
203.7±0.0 °C at 760 mmHg

[ 熔点 ]:
4-5 °C(lit.)

[ 分子式 ]:
C₄H₄O₂

[ 分子量 ]:
84.073

[ 闪点 ]:
101.1±0.0 °C

[ 精确质量 ]:
84.021126

[ PSA ]:
26.30000

[ LogP ]:
-0.84

[ 外观性状 ]:
液体;Colorless to Light orange to Yellow clear liquid

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.481

[ 储存条件 ]:
2-8°C

2(5H)-呋喃酮MSDS

2(5H)-呋喃酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LU3453000

CHEMICAL NAME :: 2(5H)-Furanone

CAS REGISTRY NUMBER :: 497-23-4

BEILSTEIN REFERENCE NO. :: 0383585

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H4-O2

MOLECULAR WEIGHT :: 84.08

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1400 mg/kg

SEX/DURATION :: female 2 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - ovaries, fallopian tubes Reproductive - Maternal Effects - uterus, cervix, vagina Reproductive - Maternal Effects - menstrual cycle changes or disorders

REFERENCE :: ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 123,571,1990

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1400 mg/kg

SEX/DURATION :: female 2 week(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Endocrine - changes in luteinizing hormone

REFERENCE :: ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948- Volume(issue)/page/year: 123,571,1990

2(5H)-呋喃酮安全信息

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
LU3453000

[ 包装等级 ]:
I; II; III

[ 海关编码 ]:
29322980

2(5H)-呋喃酮合成路线

2(5H)-呋喃酮上下游产品

2(5H)-呋喃酮上游产品

2(5H)-呋喃酮下游产品

2(5H)-呋喃酮制备

1. 烟草：FC，9， 18；FC，BU，OR，40。

2(5H)-呋喃酮海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2(5H)-呋喃酮文献

Comparative safety of the antifouling compound butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) to the marine medaka (Oryzias melastigma).

Aquat. Toxicol. 149 , 116-25, (2014)

This study evaluated the potential adverse effects of butenolide, a promising antifouling compound, using the marine medaka (Oryzias melastigma), a model fish for marine ecotoxicology. The active ingr...

Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT).

Aquat. Toxicol. 157 , 47-56, (2014)

SeaNine 211 with active ingredient of 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) has been used as a "green" antifouling agent worldwide but has raised serious biosafety concerns in coastal en...

Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death.

Toxicol. Lett. 222(1) , 64-71, (2013)

The alpha, beta-unsaturated lactones 2-furanone and 2-pyrone are part of the chemical structure of a variety of naturally occurring compounds (e.g., cardenolides, bufadienolides, acetogenins, coumarin...

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