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托曲珠利

托曲珠利用途

Toltrazuril是抗原虫化合物,对球虫亚纲有效。

托曲珠利名称

[ CAS 号 ]:
69004-03-1

[ 中文名 ]:
托曲珠利

[ 英文名 ]:
toltrazuril

[中文别名 ]:

[英文别名 ]:

Bay Vi 9142
MFCD00867201
Toltrazuril
EINECS 231-710-0

托曲珠利生物活性

[ 描述 ]:

Toltrazuril是抗原虫化合物,对球虫亚纲有效。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

天然产物 >> 其他

[参考文献]

[1]. Mehlhorn H, et al. Toltrazuril effective against a broad spectrum of protozoan parasites. Parasitol Res. 1988;75(1):64-6.

[2]. Diaferia M, et al. Efficacy of toltrazuril 5 % suspension (Baycox?, Bayer) and diclazuril (Vecoxan, Janssen-Cilag) in the control of Eimeria spp. in lambs. Parasitol Res. 2013 Aug;112 Suppl 1:163-8.

[相关活性小分子]

托曲珠利物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 熔点 ]:
194-196°C

[ 分子式 ]:
C₁₈H₁₄F₃N₃O₄S

[ 分子量 ]:
425.382

[ 精确质量 ]:
425.065704

[ PSA ]:
111.39000

[ LogP ]:
2.90

[ 折射率 ]:
1.640

[ 储存条件 ]:
0-6°C

托曲珠利安全信息

[ 符号 ]:

GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H410

[ 警示性声明 ]:
P273-P501

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
N:Dangerousfortheenvironment;

[ 风险声明 (欧洲) ]:
R50/53

[ 安全声明 (欧洲) ]:
S60-S61

[ 危险品运输编码 ]:
UN 3077

[ 海关编码 ]:
2933699090

托曲珠利合成路线

详细合成路线

托曲珠利上下游产品

托曲珠利上游产品

托曲珠利下游产品

托曲珠利海关

[ 海关编码 ]: 2933699090

[ 中文概述 ]:
2933699090 其他结构上含非稠合三嗪环化合物. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0%

托曲珠利文献

Pharmacokinetics and improved bioavailability of toltrazuril after oral administration to rabbits.

J. Vet. Pharmacol. Ther. 33(5) , 503-6, (2010)

Necrotic enteritis due to simultaneous infection with Isospora suis and clostridia in newborn piglets and its prevention by early treatment with toltrazuril.

Parasitol. Res. 110(4) , 1347-55, (2012)

In this study, 51 piglets originating from five different sows were included in the investigations. The animal source of all sows had a history of Clostridium perfringens type A (β2) infection. The pi...

Determination of diclazuril, toltrazuril and its two metabolites in poultry tissues and eggs by gel permeation chromatography-liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(20) , 1757-63, (2011)

A new procedure has been described for the extraction of diclazuril (DIZ), toltrazuril (TOZ) and its two main metabolites toltrazuril sulphoxide (TZSO) and toltrazuril sulphone (TZS) from poultry tiss...

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