<生产厂家价格>

洛索洛芬

洛索洛芬用途

Loxoprofen是非甾体抗炎化合物。

洛索洛芬名称

[ CAS 号 ]:
68767-14-6

[ 中文名 ]:
洛索洛芬

[ 英文名 ]:
Loxoprofen

[中文别名 ]:

[英文别名 ]:

IOXOPROFEN
MFCD00864331
KOLOXO
Loxoprofen

洛索洛芬生物活性

[ 描述 ]:

Loxoprofen是非甾体抗炎化合物。

[ 相关类别 ]:

研究领域 >> 炎症/免疫

[ 靶点 ]

COX-1:6.5 μM (IC50, in human whole blood)

COX-2:13.5 μM (IC50, in human whole blood)

[参考文献]

[1]. Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004 Mar 8;14(5):1201-3.

[相关活性小分子]

洛索洛芬物理化学性质

[ 密度 ]:
1.2±0.1 g/cm3

[ 沸点 ]:
417.9±20.0 °C at 760 mmHg

[ 熔点 ]:
108.5 - 111ºC

[ 分子式 ]:
C₁₅H₁₈O₃

[ 分子量 ]:
246.302

[ 闪点 ]:
220.7±18.3 °C

[ 精确质量 ]:
246.125595

[ PSA ]:
54.37000

[ LogP ]:
1.87

[ 外观性状 ]:
白色至淡黄色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.568

[ 储存条件 ]:
室温

[ 水溶解性 ]:
可溶于：甲醇

洛索洛芬MSDS

洛索洛芬安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918300090

洛索洛芬合成路线

洛索洛芬上下游产品

洛索洛芬上游产品

洛索洛芬下游产品

洛索洛芬制备

2-氧环戊烷羧酸乙酯和氢氧化钾在二甲基甲酰胺中，在80℃和2-(4-氯-基苯基)丙酸乙酯反应2h。得到的产物和47%氢溴酸反应，水解脱羧，得洛索洛芬。

洛索洛芬海关

[ 海关编码 ]: 2918300090

[ 中文概述 ]:
2918300090 其他含醛基或酮基不含其他含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

洛索洛芬文献

Determination of nonsteroidal anti-inflammatory drugs in human tear and plasma samples using ultra-fast liquid chromatography-tandem mass spectrometry.

Jpn. J. Ophthalmol. 59 , 364-71, (2015)

To evaluate a new rapid and sensitive method for analyzing human tears and plasma for nonsteroidal anti-inflammatory drugs (NSAIDs) and investigate the influence of the transfer of NSAIDs in an ocular...

Risk of peptic ulcer bleeding associated with Helicobacter pylori infection, nonsteroidal anti-inflammatory drugs, low-dose aspirin, and antihypertensive drugs: a case-control study.

J. Gastroenterol. Hepatol. 30(2) , 292-8, (2015)

The associations between antithrombotic or antihypertensive drugs and peptic ulcer bleeding (PUB) remain unknown, particularly in Asia, where Helicobacter pylori infection is prevalent. This study aim...

Effect of X-ray exposure on the pharmaceutical quality of drug tablets using X-ray inspection equipment.

Drug Dev. Ind. Pharm. 41 , 953-8, (2015)

X-ray inspection equipment is widely used to detect missing materials and defective goods in opaque containers. Its application has been expanded to the pharmaceutical industry to detect the presence ...

更多文献