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索比尼尔

索比尼尔用途

Sorbinil 是一种醛糖还原酶抑制剂 (ARI)。Sorbinil 在治疗糖尿病和糖尿病并发症方面发挥治疗作用,降低 AR 活性和抑制多元醇途径,发现它比人类使用的其它 ARI 更安全。

索比尼尔名称

[ CAS 号 ]:
68367-52-2

[ 中文名 ]:
索比尼尔

[ 英文名 ]:
Sorbinil

[英文别名 ]:

Sorbinil
Sorbinilo
Sorbinilum

索比尼尔生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 醛糖还原酶

研究领域 >> 代谢疾病

[参考文献]

[1]. Huang Q, et al. Sorbinil, an Aldose Reductase Inhibitor, in Fighting Against Diabetic Complications. Med Chem. 2019;15(1):3-7.

索比尼尔物理化学性质

[ 密度 ]:
1.52g/cm3

[ 分子式 ]:
C₁₁H₉FN₂O₃

[ 分子量 ]:
236.19900

[ 精确质量 ]:
236.06000

[ PSA ]:
67.43000

[ LogP ]:
1.30050

[ 外观性状 ]:
白色至类白色粉末

[ 折射率 ]:
1.629

[ 储存条件 ]:
2-8°C

索比尼尔安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
NONH for all modes of transport

索比尼尔文献

The isolation and characterization of β-glucogallin as a novel aldose reductase inhibitor from Emblica officinalis.

PLoS ONE 7(4) , e31399, (2012)

Diabetes mellitus is recognized as a leading cause of new cases of blindness. The prevalence of diabetic eye disease is expected to continue to increase worldwide as a result of the dramatic increase ...

Aldose reductase inhibition prevents endotoxin-induced inflammatory responses in retinal microglia.

Invest. Ophthalmol. Vis. Sci. 55(5) , 2853-61, (2014)

Retinal microglia become activated in diabetes and produce pro-inflammatory molecules associated with changes in retinal vasculature and increased apoptosis of retinal neurons and glial cells. We soug...

Aldose reductase inhibition alleviates hyperglycemic effects on human retinal pigment epithelial cells.

Chem. Biol. Interact. 234 , 254-60, (2015)

Chronic hyperglycemia is an important risk factor involved in the onset and progression of diabetic retinopathy (DR). Among other effectors, aldose reductase (AR) has been linked to the pathogenesis o...

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