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CuATSM

CuATSM用途

CuATSM是一种高效的自由基捕获抗氧化剂(RTA)和(磷酸)脂质过氧化抑制剂,因此具有抑制铁下垂的能力。

CuATSM名称

[ CAS 号 ]:
68341-09-3

[ 中文名 ]:
[[2,2′-(1,2-二甲基-1,2-乙二亚甲基)双[N-甲基肼甲硫代酰胺基]]]铜

[ 英文名 ]:
CuATSM

[英文别名 ]:

ATSM CU-64
0YDK1H9L3A
Cu-ASTM

CuATSM生物活性

[ 描述 ]:

CuATSM是一种高效的自由基捕获抗氧化剂(RTA)和(磷酸)脂质过氧化抑制剂,因此具有抑制铁下垂的能力。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> Ferroptosis

研究领域 >> 神经疾病

[参考文献]

[1]. Zilka O, et al. Radical-Trapping Antioxidant Activity of Copper and Nickel Bis(Thiosemicarbazone) Complexes Underlies Their Potency as Inhibitors of Ferroptotic Cell Death. J Am Chem Soc. 2021 Nov 17;143(45):19043-19057.

CuATSM物理化学性质

[ 分子式 ]:
C₈H₁₄CuN₆S₂

[ 分子量 ]:
321.91

[ 精确质量 ]:
321.001740

[ 外观性状 ]:
powder

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
DMSO: soluble10mg/mL, clear

CuATSM安全信息

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

CuATSM文献

Zn II(atsm) is protective in amyotrophic lateral sclerosis model mice via a copper delivery mechanism.

Neurobiol. Dis. 81 , 20-4, (2015)

Mutations in the metalloprotein Cu,Zn-superoxide dismutase (SOD1) cause approximately 20% of familial cases of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease for which effectiv...

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

J. Neurosci. 34(23) , 8021-31, (2014)

Mutations in the metallo-protein Cu/Zn-superoxide dismutase (SOD1) cause amyotrophic lateral sclerosis (ALS) in humans and an expression level-dependent phenotype in transgenic rodents. We show that o...

Therapeutic effects of CuII(atsm) in the SOD1-G37R mouse model of amyotrophic lateral sclerosis.

Amyotroph. Lateral Scler. Frontotemporal Degener. 14(7-8) , 586-90, (2013)

Our objective was to assess the copper(II) complex of diacetylbis(4-methylthiosemicarbazone) [Cu(II)(atsm)] for its preclinical potential as a novel therapeutic for ALS. Experimental paradigms used we...

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