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(TYR4)-BOMBESIN

(TYR4)-BOMBESIN用途

[Tyr4]-Bombesin 是 Bombesin 类似物,是胃泌素释放肽受体 (GRPR) 的配体。

(TYR4)-BOMBESIN名称

[ CAS 号 ]:
67338-70-9

[ 中文名 ]:
(TYR4)-BOMBESIN

[ 英文名 ]:
(Tyr4)-Bombesin

[英文别名 ]:

PYR-QRYGNQWAVGHLM-NH2
bombesin-4-L-tyrosine

(TYR4)-BOMBESIN生物活性

[ 描述 ]:

[Tyr4]-Bombesin 是 Bombesin 类似物,是胃泌素释放肽受体 (GRPR) 的配体。

[ 相关类别 ]:

研究领域 >> 代谢疾病

信号通路 >> G 蛋白偶联受体/G 蛋白 >> Bombesin Receptor

[参考文献]

[1]. Joseph Lau, et al. Effect of Radiometal on Binding Affinity and Biodistribution of ProBOMB1, a Novel Bombesin Derivative. Journal of Nuclear Medicine May 2019, 60 (supplement 1) 1013.

(TYR4)-BOMBESIN物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 分子式 ]:
C₇₄H₁₀₈N₂₄O₁₉S

[ 分子量 ]:
1669.864

[ 精确质量 ]:
1668.794312

[ PSA ]:
731.66000

[ LogP ]:
-4.93

[ 折射率 ]:
1.693

[ 储存条件 ]:
-20°C

(TYR4)-BOMBESIN安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3.0

(TYR4)-BOMBESIN文献

Bombesin receptors in distinct tissue compartments of human pancreatic diseases.

Lab. Invest. 80 , 1807-1817, (2000)

Overexpression of receptors for regulatory peptides in various human diseases is reportedly of clinical interest. Among these peptides, bombesin and gastrin-releasing peptide (GRP) have been shown to ...

Modulation of bombesin-induced phosphatidylinositol hydrolysis in a small-cell lung-cancer cell line.

Biochem. J. 255 , 403-410, (1988)

Bombesin is an amphibian tetradecapeptide whose mammalian homologue, gastrin-releasing peptide (GRP), is produced by many small-cell lung-cancer (SCLC) cells, and which can function in an autocrine gr...

Investigation of molecular structure of bombesin and its modified analogues nonadsorbed and adsorbed on electrochemically roughened silver surface.

Biopolymers 89 , 506-521, (2008)

This work describes the molecular structure of bombesin (BN) and its analogs on the basis of the absorption infrared and Raman results described below. In these analogues is replaced one ([D-Phe12]BN,...

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