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正二十二醇

正二十二醇用途

1-Docosanol是一饱和脂肪醇,报道有脂质包膜病毒,包括单纯疱疹病毒的抑制剂活性。

正二十二醇名称

[ CAS 号 ]:
661-19-8

[ 中文名 ]:
1-二十二醇

[ 英文名 ]:
1-Docosanol

[中文别名 ]:

[英文别名 ]:

Emery 3304
MFCD00002939
Docosanol
ALCOHOL C22
tadenan
lidavol
IK 2 (alcohol)
n-docosanol
behenic alcohol
Docosanol (Abreua)

正二十二醇生物活性

[ 描述 ]:

1-Docosanol是一饱和脂肪醇,报道有脂质包膜病毒,包括单纯疱疹病毒的抑制剂活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HSV

研究领域 >> 感染

[参考文献]

[1]. Katz DH, et al. Antiviral activity of 1-docosanol, an inhibitor of lipid-enveloped viruses including herpes simplex. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10825-9.

[2]. Sacks SL, et al. Clinical efficacy of topical docosanol 10% cream for herpes simplex labialis: A multicenter, randomized, placebo-controlled trial. J Am Acad Dermatol. 2001 Aug;45(2):222-30.

[相关活性小分子]

正二十二醇物理化学性质

[ 密度 ]:
0.8±0.1 g/cm3

[ 沸点 ]:
375.9±5.0 °C at 760 mmHg

[ 熔点 ]:
65-72 °C(lit.)

[ 分子式 ]:
C₂₂H₄₆O

[ 分子量 ]:
326.600

[ 闪点 ]:
142.5±5.2 °C

[ 精确质量 ]:
326.354858

[ PSA ]:
20.23000

[ LogP ]:
10.44

[ 外观性状 ]:
白色球状或薄片。不溶于水。熔点：68-72℃沸点：180 °C/0.22 mmHg

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.455

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
Insoluble

正二十二醇MSDS

正二十二醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR1315000

CHEMICAL NAME :: 1-Docosanol

CAS REGISTRY NUMBER :: 661-19-8

BEILSTEIN REFERENCE NO. :: 1770470

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C22-H46-O

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 17,879,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T2018 No. of Facilities: 151 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1358 (estimated)

正二十二醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
-

[ RTECS号 ]:
JR1315000

[ 海关编码 ]:
29051900

正二十二醇合成路线

正二十二醇制备

1. 植物油脂提取。

2. 烟草：FC，9；BU，9， 18；FC，BU，OR，14。

正二十二醇海关

[ 海关编码 ]: 29051900

正二十二醇文献

Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).

J. Sci. Ind. Res. 65(10) , 808, (2006)

Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI typ...

Surface properties of artificial tear film lipid layers: effects of wax esters.

Invest. Ophthalmol. Vis. Sci. 55(7) , 4448-54, (2014)

The tear film lipid layer is believed to stabilize the tear film and to retard evaporation. Based on previous simple in vitro studies, the evidence for the latter property is scarce. In this study, we...

Bioactive constituents in Prunus africana: geographical variation throughout Africa and associations with environmental and genetic parameters.

Phytochemistry 83 , 70-8, (2012)

Prunus africana--an evergreen tree found in Afromontane forests--is used in traditional medicine to cure benign prostate hyperplasia. Different bioactive constituents derived from bark extracts from 2...

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