2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)

2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)用途

丁基羟基甲苯-d21是氘标记的丁基羟基甲苯[1]。丁基羟基甲苯是一种抗氧化剂,广泛用于食品和食品相关产品[2]。丁基羟基甲苯是一种脱铁抑制剂[3]。

2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)名称

[ CAS 号 ]:
64502-99-4

[ 中文名 ]:
2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)

[ 英文名 ]:
Butylated hydroxytoluene-d21

[英文别名 ]:

MFCD00209760
BHT-d21

2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)生物活性

[ 描述 ]:

丁基羟基甲苯-d21是氘标记的丁基羟基甲苯[1]。丁基羟基甲苯是一种抗氧化剂,广泛用于食品和食品相关产品[2]。丁基羟基甲苯是一种脱铁抑制剂[3]。

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞凋亡 >> Ferroptosis

[体外研究]

氢、碳和其他元素的稳定重同位素已被掺入药物分子中,主要作为药物开发过程中定量的示踪剂。头韵因其可能影响药物的药代动力学和代谢特征而受到关注[1]。

[参考文献]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

[2]. Babich H, et al. Butylated hydroxytoluene (BHT): a review. Environ Res. 1982 Oct;29(1):1-29.

[3]. Umemura T, et al. Butylhydroxytoluene (BHT) increases susceptibility of transgenic rasH2 mice to lung carcinogenesis. J Cancer Res Clin Oncol. 2001 Oct127(10):583-90.

[4]. Stockwell BR, et al. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. ell. 2017 Oct 5171(2):273-285.

2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)物理化学性质

[ 沸点 ]:
265ºC(lit.)

[ 熔点 ]:
69-71ºC(lit.)

[ 分子式 ]:
C₁₅H₃D₂₁O

[ 分子量 ]:
241.48000

[ 精确质量 ]:
241.31500

[ PSA ]:
20.23000

[ LogP ]:
4.29560

2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)MSDS

详细MSDS(安全技术说明书)

2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H411

[ 警示性声明 ]:
P273-P305 + P351 + P338

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
20/21/22-36/37/38

[ 安全声明 (欧洲) ]:
7-22-26-37/39

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

2,6-二(叔丁基-d9)-4-甲基(苯酚-3,5,O-d3)文献

Determination of synthetic phenolic antioxidants and relative metabolites in sewage treatment plant and recipient river by high performance liquid chromatography-electrospray tandem mass spectrometry.

J. Chromatogr. A. 1381 , 13-21, (2015)

Robust analytical methods were developed for the determination of eight emerging synthetic phenolic antioxidants (SPAs) and three metabolites in sewage sludge, effluent and river water matrices. Accel...

Synthetic Phenolic Antioxidants and Their Metabolites in Indoor Dust from Homes and Microenvironments.

Environ. Sci. Technol. 50 , 428-34, (2016)

Synthetic phenolic antioxidants (SPAs), including 2,6-di-tert-butyl-4-hydroxytoluene (BHT), are extensively used in food, cosmetic and plastic industries. Nevertheless, limited information is availabl...

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