hygromycin A

hygromycin A用途

潮霉素A是伯氏疏螺旋体的选择性抗生素。潮霉素A是一种螺旋体特异性抗菌剂,有利于肠道健康。潮霉素A可用于莱姆病的研究[1]。

hygromycin A名称

[ CAS 号 ]:
6379-56-2

[ 英文名 ]:
hygromycin A

[英文别名 ]:

Homomycin
Totomycin
Homomycin (6CI)
Hygromycin A

hygromycin A生物活性

[ 描述 ]:

潮霉素A是伯氏疏螺旋体的选择性抗生素。潮霉素A是一种螺旋体特异性抗菌剂,有利于肠道健康。潮霉素A可用于莱姆病的研究[1]。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体内研究]

潮霉素A选择性杀死伯氏疏螺旋体并对肠道菌群组成产生有利影响,从而导致益生菌[1]

[参考文献]

[1]. Arnaboldi PM, et al. Hygromycin A in the Lymelight. Cell Host Microbe. 2021 Nov 10;29(11):1599-1601.

hygromycin A物理化学性质

[ 分子式 ]:
C₂₃H₂₉NO₁₂

[ 分子量 ]:
511.48

[ 精确质量 ]:
511.16900

[ PSA ]:
207.96000

hygromycin A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NG8859000

CHEMICAL NAME :: D-nes-Inositol, 5-deoxy-5-((3-(4-((6-deoxy-beta-D-arabino-hexofuranos -5-ulos-1-yl)oxy)-3- hydroxyphenyl)-2-methyl-1-oxo-2-propenyl)amino)-1,2-O -methylene-, (E)-

CAS REGISTRY NUMBER :: 6379-56-2

LAST UPDATED :: 198909

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H29-N-O12

MOLECULAR WEIGHT :: 511.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1067 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85FZAT "Index of Antibiotics from Actinomycetes," Umezawa, H. et al., eds., Tokyo, Univ. of Tokyo Press, 1967 Volume(issue)/page/year: -,656,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 6,332,1981