盐酸嘧啶二胺
盐酸嘧啶二胺名称
[ CAS 号 ]:
63-56-9
[ 中文名 ]:
盐酸嘧啶二胺
[ 英文名 ]:
thonzylamine hydrochloride
[英文别名 ]:
- Novohetramin
- Thonzylaminium chloride
- Anahist
- EINECS 200-561-3
- Thonzylamine HCl
- UNII-6K9YKD48Y4
- THONZYLAMINE HYDROCHLORIDE
- Resistab
- Neohetramine hydrochloride
盐酸嘧啶二胺物理化学性质
[ 密度 ]:
1.2562 (rough estimate)
[ 沸点 ]:
bp2.2 185-187°
[ 熔点 ]:
173 - 176ºC
[ 分子式 ]:
C16H23ClN4O
[ 分子量 ]:
322.833
[ 闪点 ]:
220.3ºC
[ 精确质量 ]:
322.156036
[ PSA ]:
41.49000
[ LogP ]:
2.85540
[ 外观性状 ]:
白色结晶粉末
[ 折射率 ]:
1.5800 (estimate)
[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.
盐酸嘧啶二胺毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UV8750000
- CHEMICAL NAME :
- Pyrimidine, 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-, hydrochloride
- CAS REGISTRY NUMBER :
- 63-56-9
- LAST UPDATED :
- 198812
- DATA ITEMS CITED :
- 6
- MOLECULAR FORMULA :
- C16-H22-N4-O.Cl-H
- MOLECULAR WEIGHT :
- 322.88
- WISWESSER LINE NOTATION :
- T6N CNJ BN1R DO1&2N1&1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 245 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 123,419,1960
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 157 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,83S,1956
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 493 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,536,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 38200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 113,313,1958 *** REVIEWS *** TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974
盐酸嘧啶二胺安全信息
[ 危害码 (欧洲) ]:
Xn
[ 风险声明 (欧洲) ]:
20/21/22
[ 安全声明 (欧洲) ]:
36
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