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SKF 38393盐酸盐

SKF 38393盐酸盐用途

SKF 38393盐酸盐是一种多巴胺D1受体激动剂, IC50为110 nM.

SKF 38393盐酸盐名称

[ CAS 号 ]:
62717-42-4

[ 中文名 ]:
SKF 38393盐酸盐

[ 英文名 ]:
SKF38393 HCl

[英文别名 ]:

SKF 38393 (hydrochloride)

SKF 38393盐酸盐生物活性

[ 描述 ]:

SKF 38393盐酸盐是一种多巴胺D1受体激动剂, IC50为110 nM.

[ 相关类别 ]:

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 多巴胺受体

信号通路 >> 神经信号通路 >> 多巴胺受体

研究领域 >> 神经疾病

[参考文献]

[1]. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222.

[2]. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-1070.

[3]. Chocyk A, et al. Dopamine D1-like receptors agonist SKF 38393 increases cFOS expression in the paraventricular nucleus of the hypothalamus--impact of acute and chronic cocaine. J Physiol Pharmacol. 2008 Sep;59(3):425-440.

[相关活性小分子]

SKF 38393盐酸盐物理化学性质

[ 分子式 ]:
C₁₆H₁₈ClNO₂

[ 分子量 ]:
291.773

[ 精确质量 ]:
291.102600

[ PSA ]:
52.49000

[ LogP ]:
3.50620

[ 外观性状 ]:
粉末

[ 储存条件 ]:
-20℃

SKF 38393盐酸盐MSDS

详细MSDS(安全技术说明书)

SKF 38393盐酸盐安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
36/37/38

[ 安全声明 (欧洲) ]:
22-26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

SKF 38393盐酸盐文献

Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.

BMC Neurosci. 11 , 7, (2010)

There is an urgent need of neuronal cell models to be applied to high-throughput screening settings while recapitulating physiological and/or pathological events occurring in the Central Nervous Syste...

Inhibition of adult rat retinal ganglion cells by D1-type dopamine receptor activation.

J. Neurosci. 29 , 15001-16, (2009)

The spike output of neural pathways can be regulated by modulating output neuron excitability and/or their synaptic inputs. Dopaminergic interneurons synapse onto cells that route signals to mammalian...

Dopaminergic regulation of mate competition aggression and aromatase-Fos colocalization in vasotocin neurons.

Neuropharmacology 58 , 117-25, (2010)

Recent experiments demonstrate that aggressive competition for potential mates involves different neural mechanisms than does territorial, resident-intruder aggression. However, despite the obvious im...

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