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马来酸氟伏沙明

马来酸氟伏沙明用途

Fluvoxamine马来酸盐是5-羟色胺再吸收抑制剂,有抗抑郁活性。

马来酸氟伏沙明名称

[ CAS 号 ]:
61718-82-9

[ 中文名 ]:
马来酸氟伏沙明

[ 英文名 ]:
Fluvoxamine maleat

[中文别名 ]:

[英文别名 ]:

MFCD00269809
EINECS 228-994-3
DU 23000 {Maleate}
faverin50
Fluvoxamine Maleat
Fluvoxamine (maleate)
SME 3110 {Maleate}
(E)-fluvoxamine maleate
MK 264 {Maleate}
Fluvoxamine maleate

马来酸氟伏沙明生物活性

[ 描述 ]:

Fluvoxamine马来酸盐是5-羟色胺再吸收抑制剂,有抗抑郁活性。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 5-羟色胺转运蛋白

研究领域 >> 神经疾病

[参考文献]

[1]. Ginsburg, B.C., J.W. Pinkston, and R.J. Lamb, The potency of fluvoxamine to reduce ethanol self-administration decreases with concurrent availability of food. Behav Pharmacol, 2012. 23(2): p. 134-42.

[2]. Claassen, V., et al., Fluvoxamine, a specific 5-hydroxytryptamine uptake inhibitor. Br J Pharmacol, 1977. 60(4): p. 505-16.

[3]. Escalona, R., et al., Fluvoxamine treatment in veterans with combat-related post-traumatic stress disorder. Depress Anxiety, 2002. 15(1): p. 29-33.

[相关活性小分子]

马来酸氟伏沙明物理化学性质

[ 沸点 ]:
370.6ºC at 760 mmHg

[ 熔点 ]:
120-121.5ºC

[ 分子式 ]:
C₁₉H₂₅F₃N₂O₆

[ 分子量 ]:
434.407

[ 闪点 ]:
177.9ºC

[ 精确质量 ]:
434.166473

[ PSA ]:
131.44000

[ LogP ]:
3.61360

[ 外观性状 ]:
白色结晶粉末

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
H2O: soluble

马来酸氟伏沙明MSDS

马来酸氟伏沙明毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SA9230000

CAS REGISTRY NUMBER :: 61718-82-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C15-H21-F3-N2-O2.C4-H4-O4

MOLECULAR WEIGHT :: 434.46

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,4149,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 29120 mg/kg/13W-I

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from stomach Liver - changes in liver weight Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,4149,1994

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 6825 mg/kg/13W-I

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in platelet count

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 28,4169,1994

马来酸氟伏沙明安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SA9230000

[ 海关编码 ]:
2928000090

马来酸氟伏沙明合成路线

马来酸氟伏沙明上下游产品

马来酸氟伏沙明上游产品

马来酸氟伏沙明下游产品

马来酸氟伏沙明海关

[ 海关编码 ]: 2928000090

[ 中文概述 ]:
2928000090 其他肼（联氨）及胲（羟胺）的有机衍生物。监管条件:无。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

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