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哌拉西林

哌拉西林用途

哌拉西林是一种半合成青霉素。哌拉西林对革兰氏阳性和革兰氏阴性需氧菌和厌氧菌具有广谱活性。哌拉西林对产生β-内酰胺酶的微生物的活性高于其他青霉素[1]。

哌拉西林名称

[ CAS 号 ]:
61477-96-1

[ 中文名 ]:
哌拉西林

[ 英文名 ]:
Piperacillin

[中文别名 ]:

[英文别名 ]:

Pipercillin
PIPC
EINECS 262-811-8
PIPERACILLIN SODIUM
PIPERACILLIN NA
Piperacillin anhydrous
MFCD00917471
PIPERAILLIN
Pipracil

哌拉西林生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. B. Holmes, et al. A Review of its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Use.

哌拉西林物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 熔点 ]:
139-140ºC

[ 分子式 ]:
C₂₃H₂₇N₅O₇S

[ 分子量 ]:
517.555

[ 精确质量 ]:
517.163147

[ PSA ]:
181.73000

[ LogP ]:
1.88

[ 外观性状 ]:
白色结晶粉末

[ 折射率 ]:
1.678

[ 储存条件 ]:
Hygroscopic, -20°C Freezer, Under Inert Atmosphere

哌拉西林毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XH8952200

CHEMICAL NAME :: 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-6-(((((4-ethyl-2,3-dioxo- 1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-7-ox o-, (2S-(2-alpha,5-alpha,6-beta(S*)))-

CAS REGISTRY NUMBER :: 61477-96-1

LAST UPDATED :: 199706

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C23-H27-N5-O7-S

MOLECULAR WEIGHT :: 517.61

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 97,987,1977 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5651 No. of Facilities: 148 (estimated) No. of Industries: 1 No. of Occupations: 4 No. of Employees: 9665 (estimated) No. of Female Employees: 8470 (estimated)

哌拉西林安全信息

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
42/43

[ 安全声明 (欧洲) ]:
36/37

[ 海关编码 ]:
2941101900

哌拉西林合成路线

详细合成路线

哌拉西林上下游产品

哌拉西林上游产品

哌拉西林下游产品

哌拉西林制备

【方法一】
可用β-羟乙胺为起始原料，经溴化、胺化、环合、酰氯化后，制得铡链EPCP。然后与6-APA（6-氨基青霉烷酸）缩合制得哌拉西林。

哌拉西林海关

[ 海关编码 ]: 2941101900