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2,4,6三碘苯酚

2,4,6三碘苯酚用途

2,4,6-三碘苯酚是一种口服活性和有效的白三烯B4(LTB4)合成抑制剂。2,4,6-三碘苯酚可诱导小鼠囊胚凋亡[1][2]。

2,4,6三碘苯酚名称

[ CAS 号 ]:
609-23-4

[ 中文名 ]:
2,4,6-三碘苯酚

[ 英文名 ]:
2,4,6-Triiodophenol

[中文别名 ]:

[英文别名 ]:

2,6-Triiodophenol
2,4,6-Triiodophenol
Phenol,4,6-triiodo
2,4,6-Trijodfenol
triiodo-2,4,6 phenol
2,3-DIHYDROXYL QUINOXALINE
Phenol, 2,4,6-triiodo-
Phenol,2,4,6-triiodo
EINECS 210-186-7
2,4,6-Trijodfenol [Czech]

2,4,6三碘苯酚生物活性

[ 描述 ]:

2,4,6-三碘苯酚是一种口服活性和有效的白三烯B4(LTB4)合成抑制剂。2,4,6-三碘苯酚可诱导小鼠囊胚凋亡[1][2]。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 其他

[体外研究]

2,4,6-三碘苯酚(5-50μM；0-100小时)以剂量依赖的方式损害植入前小鼠胚胎的质量,导致总细胞数和滋养外胚层细胞数下降[2]。2,4,6-三碘苯酚(5 μM；85 h)显示小鼠植入前胚胎中凋亡细胞的增加[2]。2,4,6-三碘苯酚(5-50 μM；100h)诱导小鼠植入前胚胎中的氧化应激[2]。细胞凋亡分析[2]细胞系：小鼠囊胚细胞浓度：5 μM培养时间：85 小时结果：显示激活的Caspase-3/7的信号。免疫荧光[2]细胞系：小鼠囊胚细胞浓度：5-50 μM培养时间：100 结果：高剂量的2,4,6-三碘苯酚处理导致氧物种(ROS)显著增加。

2,4,6三碘苯酚物理化学性质

[ 密度 ]:
3.1±0.1 g/cm3

[ 沸点 ]:
316.3±42.0 °C at 760 mmHg

[ 熔点 ]:
157-159 °C(lit.)

[ 分子式 ]:
C₆H₃I₃O

[ 分子量 ]:
471.801

[ 闪点 ]:
145.1±27.9 °C

[ 精确质量 ]:
471.731781

[ PSA ]:
20.23000

[ LogP ]:
3.88

[ 外观性状 ]:
灰色至黄褐色的至棕色粉末

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.816

[ 储存条件 ]:
室温，密封，干燥，惰性气体环境

2,4,6三碘苯酚MSDS

详细MSDS(安全技术说明书)

2,4,6三碘苯酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SN2800000

CHEMICAL NAME :: Phenol, 2,4,6-triiodo-

CAS REGISTRY NUMBER :: 609-23-4

BEILSTEIN REFERENCE NO. :: 2046861

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H3-I3-O

MOLECULAR WEIGHT :: 471.79

WISWESSER LINE NOTATION :: QR BI DI FI

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >4 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 18,642,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03493

2,4,6三碘苯酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H312 + H332-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SN2800000

[ 海关编码 ]:
2908199090

2,4,6三碘苯酚合成路线

详细合成路线

2,4,6三碘苯酚上下游产品

2,4,6三碘苯酚上游产品

2,4,6三碘苯酚下游产品

2,4,6三碘苯酚海关

[ 海关编码 ]: 2908199090

[ 中文概述 ]:
HS:2908199090 其他酚及酚醇的仅含卤素取代基的衍生物及其盐增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:5.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
HS: 2908199090. derivatives of polyphenols or phenol-alcohols containing only halogen substituents and their salts. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:None. MFN tariff:5.5%. general tariff:30.0%

2,4,6三碘苯酚文献

Distribution of dehalogenation activity in subseafloor sediments of the Nankai Trough subduction zone.

Philos. Trans. R. Soc. Lond., B, Biol. Sci. 368(1616) , 20120249, (2013)

Halogenated organic matter buried in marine subsurface sediment may serve as a source of electron acceptors for anaerobic respiration of subseafloor microbes. Detection of a diverse array of reductive...

Comparative developmental toxicity of new aromatic halogenated DBPs in a chlorinated saline sewage effluent to the marine polychaete Platynereis dumerilii.

Environ. Sci. Technol. 47(19) , 10868-76, (2013)

Using seawater for toilet flushing may introduce high levels of bromide and iodide into a city's sewage treatment works, and result in the formation of brominated and iodinated disinfection byproducts...

Fast speciation analysis of iodophenol compounds in river waters by capillary electrophoresis-inductively coupled plasma-mass spectrometry with off-line solid-phase microextraction.

Electrophoresis 25(12) , 1843-51, (2004)

An analytical methodology for the fast separation and determination of iodophenol species in natural water samples was developed using capillary electrophoresis (CE) coupled to inductively coupled pla...

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