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甲基丙二酸二乙酯

甲基丙二酸二乙酯用途

用作有机合成中间体
本品可用于合成二丙基丙二酸,进一步合成抗癫痫药物抗癫灵等。

甲基丙二酸二乙酯名称

[ CAS 号 ]:
609-08-5

[ 中文名 ]:
甲基丙二酸二乙酯

[ 英文名 ]:
Ethyl methylmalonate

[中文别名 ]:

甲基丙乙酸二乙酯

[英文别名 ]:

Ethyl methylmalonate
Propanedioic acid, 2-methyl-, diethyl ester
Propanedioic acid, methyl-, diethyl ester
MFCD00009162
Ethyl methylmalonate (VAN)
diethyl 2-methylpropanedioate
diethyl 2-methylmalonate
EINECS 210-175-7
Diethyl methylmalonate
Diethyl ethanedicarboxylate

甲基丙二酸二乙酯物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
204.4±8.0 °C at 760 mmHg

[ 分子式 ]:
C₈H₁₄O₄

[ 分子量 ]:
174.194

[ 闪点 ]:
76.7±0.0 °C

[ 精确质量 ]:
174.089203

[ PSA ]:
52.60000

[ LogP ]:
1.05

[ 外观性状 ]:
透明液体

[ 蒸汽压 ]:
0.3±0.4 mmHg at 25°C

[ 折射率 ]:
1.421

[ 储存条件 ]:
室温，密封

[ 水溶解性 ]:
immiscible

甲基丙二酸二乙酯MSDS

甲基丙二酸二乙酯安全信息

[ 个人防护装备 ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S23-S24/25

[ WGK德国 ]:
3

[ 海关编码 ]:
2917190090

甲基丙二酸二乙酯合成路线

甲基丙二酸二乙酯上下游产品

甲基丙二酸二乙酯上游产品

甲基丙二酸二乙酯下游产品

甲基丙二酸二乙酯制备

将草酰丙酸二乙酯加热至激烈逸出一氧化碳，温度130-150℃。放出的气体减少后，逐步上升高温度，使液体回流直至气体逸尽。蒸馏得甲基丙二酸二乙酯，收率97%。

甲基丙二酸二乙酯海关

[ 海关编码 ]: 2917190090

[ 中文概述 ]:
2917190090 其他无环多元羧酸. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 对苯二甲酸请注明4-CBA值, 对苯二甲酸请注明P-TL酸值, 对苯二甲酸请注明色度, 对苯二甲酸请注明水分

[ Summary ]:
2917190090 acyclic polycarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

甲基丙二酸二乙酯文献

An erythromycin process improvement using the diethyl methylmalonate-responsive (Dmr) phenotype of the Saccharopolyspora erythraea mutB strain.

Appl. Microbiol. Biotechnol. 93(4) , 1575-83, (2012)

The Saccharopolyspora erythraea mutB knockout strain, FL2281, having a block in the methylmalonyl-CoA mutase reaction, was found to carry a diethyl methylmalonate-responsive (Dmr) phenotype in an oil-...

Abnormal Michael reaction. Reaction between 2-cyclohexenone and diethyl methylmalonate. Risinger GE and Haag WG.

J. Org. Chem. 38(20) , 3546-3647, (1973)

Alkylation reaction of poly (chloromethylstyrene) with malononitrile and diethyl methylmalonate using phase transfer catalysts. Nishikubo T, et al.

Makromol. Chem. 2(6-7) , 387-392, (1981)

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