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对氨基水杨酸钠

对氨基水杨酸钠用途

Sodium 4-aminosalicylate dihydrate 是一抗耐药性结核化合物。

对氨基水杨酸钠名称

[ CAS 号 ]:
6018-19-5

[ 中文名 ]:
对氨基水杨酸钠

[ 英文名 ]:
Sodium 4-aminosalicylate dihydrate

[中文别名 ]:

[英文别名 ]:

Sodium 4-Aminosalicylate
EINECS 205-091-2
4-Aminosalicylic acid sodium salt dihydrate
AMINOSALICYLATE SODIUM,DIHYDRATE
4-AMINOSALICYLIC ACID,NA SALT
Sodium 4-amino-2-hydroxybenzoate dihydrate
4-AMINOSALICYLIC ACID SODIUM SALT 2-HYDRATE
4-Amino-2-hydroxy-benzoesaeure,Natrium-Salz
4-AMINOSALICYLIC ACID SODIUM DIHYDRATE
sodium p-aminosalicylate dihydrate

对氨基水杨酸钠生物活性

[ 描述 ]:

Sodium 4-aminosalicylate dihydrate 是一抗耐药性结核化合物。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Zheng J, et al. para-Aminosalicylic acid is a prodrug targeting dihydrofolate reductase in Mycobacterium tuberculosis. J Biol Chem. 2013 Aug 9;288(32):23447-56.

[2]. Sy SK, et al. N-acetyltransferase genotypes and the pharmacokinetics and tolerability of para-aminosalicylic acid in drug-resistant pulmonary tuberculosis patients. Antimicrob Agents Chemother. 2015 May 11. pii: AAC.04049-14.

[相关活性小分子]

对氨基水杨酸钠物理化学性质

[ 沸点 ]:
380.8ºC at 760 mmHg

[ 熔点 ]:
250 °C

[ 分子式 ]:
C₇H₁₀NNaO₅

[ 分子量 ]:
211.148

[ 闪点 ]:
184.1ºC

[ 精确质量 ]:
211.045670

[ PSA ]:
104.84000

[ 外观性状 ]:
白色至米色细结晶粉末

[ 储存条件 ]:
室温

[ 水溶解性 ]:
soluble

对氨基水杨酸钠MSDS

详细MSDS(安全技术说明书)

对氨基水杨酸钠安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi: Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918219000

对氨基水杨酸钠海关

[ 海关编码 ]: 2922509090

[ 中文概述 ]:
2922509090. 其他氨基醇酚、氨基酸酚及其他含氧基氨基化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件：AB. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验

[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

对氨基水杨酸钠文献

Adsorption of phenolic compounds from aqueous solution using salicylic acid type adsorbent.

J. Hazard. Mater. 201-202 , 74-81, (2012)

In this study, 5-aminosalicylic acid (5-ASA) was successfully grafted onto the poly(glycidyl methacrylate) (PGMA) macromolecular chains of PGMA/SiO(2) to obtain adsorbent ASA-PGMA/SiO(2). The adsorpti...

Comparison between 5-aminosalicylic acid (5-ASA) and para-aminosalicylic acid (4-PAS) as potential protectors against Mn-induced neurotoxicity.

Biol. Trace Elem. Res. 152(1) , 113-6, (2013)

Manganese (Mn) is an essential metal for biological systems; however, occupational or clinical exposure to high levels of Mn can produce a neurological disorder called manganism. Oxidative stress and ...

Liver-selective expression of human arylamine N-acetyltransferase NAT2 in transgenic mice.

Drug Metab. Dispos. 39(5) , 882-90, (2011)

Human arylamine N-acetyltransferase 2 (NAT2) mediates the biotransformation of arylamine drugs and procarcinogens into either innocuous or reactive DNA-damaging metabolites and is expressed predominan...

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