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亚油酸

亚油酸用途

Linoleic acid 是多不饱和脂肪酸的一种关键组分。

亚油酸名称

[ CAS 号 ]:
60-33-3

[ 中文名 ]:
亚油酸

[ 英文名 ]:
Linoleic acid

[中文别名 ]:

[英文别名 ]:

MFCD00064241
cis,cis-9,12-octadecadienoic acid
Pamolyn
9,12-Octadecadienoic acid, (9Z,12Z)-
FEMA 3380
Hidiene
cis-9,cis-12-octadecadienoic acid
Linoleic acid
LINOLEATE
emersol310

亚油酸生物活性

[ 描述 ]:

Linoleic acid 是多不饱和脂肪酸的一种关键组分。

[ 相关类别 ]:

天然产物 >> 酸和醛

研究领域 >> 其他

[ 靶点 ]

Human Endogenous Metabolite

[体外研究]

亚油酸含有不饱和双键,非常容易受到自由基攻击和氧化的影响。如果大量产生ROS,身体就不能再有效地去除它们。在这种情况下,ROS可能被释放到细胞外空间,导致对周围细胞和组织的损害。亚油酸是游离脂肪酸的分解产物,与红细胞损伤有关[1]。

[参考文献]

[1]. Yuan T, et al. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. Int J Clin Exp Pathol. 2015 May 1;8(5):5044-52.

[相关活性小分子]

亚油酸物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
360.6±0.0 °C at 760 mmHg

[ 熔点 ]:
-5 °C

[ 分子式 ]:
C₁₈H₃₂O₂

[ 分子量 ]:
280.445

[ 闪点 ]:
273.0±14.4 °C

[ 精确质量 ]:
280.240234

[ PSA ]:
37.30000

[ LogP ]:
7.18

[ 外观性状 ]:
无色或淡黄色液体

[ 蒸汽压 ]:
0.0±1.7 mmHg at 25°C

[ 折射率 ]:
1.478

[ 储存条件 ]:
2-8°C

[ 稳定性 ]:
Stability Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents.

[ 水溶解性 ]:
INSOLUBLE

[ 凝固点 ]:
-5℃

亚油酸MSDS

亚油酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: RF9990000

CHEMICAL NAME :: 9,12-Octadecadienoic acid, (Z)-

CAS REGISTRY NUMBER :: 60-33-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C18-H32-O2

MOLECULAR WEIGHT :: 280.50

WISWESSER LINE NOTATION :: QV8U3U6

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Human

REFERENCE :: 85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 4,327,1970

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3728459

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 104,793,1984 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 43040 No. of Facilities: 4852 (estimated) No. of Industries: 61 No. of Occupations: 64 No. of Employees: 45762 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 43040 No. of Facilities: 2186 (estimated) No. of Industries: 26 No. of Occupations: 37 No. of Employees: 57612 (estimated) No. of Female Employees: 16829 (estimated)

亚油酸安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
R36

[ 安全声明 (欧洲) ]:
S26-S24/25-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
RF9990000

[ 海关编码 ]:
2916150000

亚油酸合成路线

亚油酸上下游产品

亚油酸上游产品

亚油酸下游产品

亚油酸制备

1.亚油酸以甘油酯的形式与其他脂肪酸一起存在于动物脂肪中。动物脂肪中的含量一般较低，如牛油1.8%，猪油为6%；若干种植物油中含量较高，如花生油为26%，菜油为15.8%，而大豆所含脂肪酸则以亚油酸为主。大豆油脂肪酸一般组成如下：油酸 15-33%亚油酸 53-56%亚麻酸 5-9%棕榈酸 7-11%硬脂酸 2-6%C20以上酸 0.3-3%大豆油在精炼过程中约有5-10%的油脚和皂脚成生。豆油皂脚中有一半是有用的脂肪酸，而皂脚中脂肪酸又与大豆油所含脂肪酸组成基本上是一致的。因此利用大豆油皂脚提取亚油酸是大豆油综合利用的重要途径。

2.以玉米油为原料的提取法

3. 用硒在200ºC或氮的氧化物处理时，转变为反亚油酸，氢化时先变为油酸和十八烯-12-酸，再变为硬脂酸。

4. 烟草：OR，44；FC，9， 13， 18， 19， 38， 41， 44， 50；OR，26；BU，9；BU，OR，18；BU，10；BU，OR，19。

亚油酸海关

[ 海关编码 ]: 2916190090

[ 中文概述 ]:
2916190090 其他不饱和无环一元羧酸（包括其酸酐、酰卤化物，过氧化物和过氧酸以及它们的衍生物）。监管条件:AB(入境货物通关单,出境货物通关单)。增值税率:17.0%。退税率:9.0%。最惠国关税:6.5%。普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 丙烯酸、丙烯酸盐或酯应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

亚油酸文献

Sensing of triacylglycerol in the gut: different mechanisms for fatty acids and 2-monoacylglycerol.

J. Physiol. 593(8) , 2097-109, (2015)

Sensing of dietary triacylglycerol in the proximal small intestine results in physiological, hormonal and behavioural responses. However, the exact physiological pathways linking intestinal fat sensin...

Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models.

Clin. Exp. Allergy 44(12) , 1515-24, (2014)

Atopic dermatitis is an inflammatory skin disease that is characterized by a reduced skin barrier function, reduced filaggrin (FLG) expression as well as increased colonization by Staphylococcus aureu...

Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model.

Stem Cells Transl. Med. 3(12) , 1514-25, (2014)

Mesenchymal stromal cells (MSCs) have received much attention as a potential treatment of ischemic diseases, including ischemic tissue injury and cardiac failure. The beneficial effects of MSCs are th...

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亚油酸