三丁酸甘油酯

三丁酸甘油酯用途

Tributyrin (Glyceryl tributyrate) 是一种中性短链脂肪酸甘油三酯,是一种稳定、吸收迅速的丁酸前药。Tributyrin (Glyceryl tributyrate) 通过细胞膜扩散并被细胞内脂肪酶代谢,在体内直接释放有效的丁酸盐到细胞内。Tributyrin (Glyceryl tributyrate) 具有有效的抗增殖、促凋亡 (apoptosis) 和诱导分化作用。

三丁酸甘油酯名称

[ CAS 号 ]:
60-01-5

[ 中文名 ]:
甘油三丁酸酯

[ 英文名 ]:
butyrin

[中文别名 ]:

[英文别名 ]:

Tributyrinine
MFCD00009392
1,2,3-Propanetriyl tributanoate
Butanoic acid, 1,2,3-propanetriyl ester
Propane-1,2,3-triyl tributanoate
Tributyroin
glyceryl tributyrate
Tributin
Butyryl triglyceride
Glycerol tributyrate

三丁酸甘油酯生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 代谢疾病

[参考文献]

[1]. T Gaschott, et al. Tributyrin, a stable and rapidly absorbed prodrug of butyric acid, enhances antiproliferative effects of dihydroxycholecalciferol in human colon cancer cells. J Nutr. 2001 Jun;131(6):1839-43.

[2]. Claudia P Schröder, et al. Tributyrin-induced differentiation promotes apoptosis of LS 174T colon cancer cells in vitro. Int J Oncol. 2002 Jan;20(1):195-200.

三丁酸甘油酯物理化学性质

[ 密度 ]:
1.1±0.1 g/cm3

[ 沸点 ]:
307.5±0.0 °C at 760 mmHg

[ 熔点 ]:
-75 °C

[ 分子式 ]:
C₁₅H₂₆O₆

[ 分子量 ]:
302.363

[ 闪点 ]:
173.9±0.0 °C

[ 精确质量 ]:
302.172943

[ PSA ]:
78.90000

[ LogP ]:
2.95

[ 外观性状 ]:
无色液体

[ 蒸汽压 ]:
0.0±0.6 mmHg at 25°C

[ 折射率 ]:
1.448

[ 储存条件 ]:
Store at RT.

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

三丁酸甘油酯MSDS

详细MSDS(安全技术说明书)

三丁酸甘油酯毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ET7350000

CHEMICAL NAME :: Butyrin, tri-

CAS REGISTRY NUMBER :: 60-01-5

BEILSTEIN REFERENCE NO. :: 1714746

LAST UPDATED :: 199707

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H26-O6

MOLECULAR WEIGHT :: 302.41

WISWESSER LINE NOTATION :: 3VO1YOV3&1OV3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LC - Lethal concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >75 ppm/6H

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: APSCAX Acta Physiologica Scandinavica. (Karolinska Institutet, S-10401 Stockholm, Sweden) V.1- 1940- Volume(issue)/page/year: 40,338,1957 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 177 gm/kg/3W-C

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors

REFERENCE :: JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 10,361,1949

三丁酸甘油酯安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
1

[ RTECS号 ]:
ET7350000

[ 海关编码 ]:
2915900090

三丁酸甘油酯合成路线

详细合成路线

三丁酸甘油酯上下游产品

三丁酸甘油酯上游产品

三丁酸甘油酯下游产品

三丁酸甘油酯制备

由丁酸和甘油在硫酸催化下经酯化反应制得。

三丁酸甘油酯海关

[ 海关编码 ]: 2915900090

[ 中文概述 ]:
2915900090. 其他饱和无环一元羧酸及其酸酐（酰卤、过氧）化物、过氧酸及其卤化、硝化、磺化、亚硝化衍生物. 增值税率:17.0%. 退税率:9.0%. 监管条件:AB(入境货物通关单,出境货物通关单). 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

三丁酸甘油酯文献

Solid lipid particles for oral delivery of peptide and protein drugs III - the effect of fed state conditions on the in vitro release and degradation of desmopressin.

AAPS J. 16(4) , 875-83, (2014)

The effect of food intake on the release and degradation of peptide drugs from solid lipid particles is unknown and was therefore investigated in vitro using different fed state media in a lipolysis m...

Biochemistry of lipolytic enzymes secreted by Penicillium solitum and Cladosporium cladosporioides.

Biosci. Biotechnol. Biochem. 78(2) , 245-54, (2014)

Two distinct extracellular lipases were obtained from Penicillium solitum 194A, isolated from domestic compost, and Cladosporium cladosporioides 194B, isolated from dairy wastewater. These alkaline en...

Candida rugosa lipase immobilization on hydrophilic charged gold nanoparticles as promising biocatalysts: Activity and stability investigations.

Colloids Surf. B Biointerfaces 131 , 93-101, (2015)

In this work, a simple and versatile methodology to obtain two different bioconjugated systems has been developed by the immobilization of Candida rugosa lipase (CRL) on hydrophilic gold nanoparticles...

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