4-羟基咪达唑仑

4-羟基咪达唑仑名称

[ CAS 号 ]:
59468-85-8

[ 中文名 ]:
4-羟基咪达唑仑

[ 英文名 ]:
8-chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepin-4-ol

[中文别名 ]:

4-羟基咪哒唑伦

[英文别名 ]:

4-OH-Mdz
4-hydroxy-MDZ
4-Hydroxy Midazolam

4-羟基咪达唑仑物理化学性质

[ 密度 ]:
1.44g/cm3

[ 沸点 ]:
550.6ºC at 760 mmHg

[ 熔点 ]:
186-187ºC

[ 分子式 ]:
C₁₈H₁₃ClFN₃O

[ 分子量 ]:
341.76700

[ 闪点 ]:
286.8ºC

[ 精确质量 ]:
341.07300

[ PSA ]:
50.41000

[ LogP ]:
3.25070

[ 折射率 ]:
1.688

4-羟基咪达唑仑安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

4-羟基咪达唑仑合成路线

详细合成路线

4-羟基咪达唑仑上下游产品

4-羟基咪达唑仑上游产品

4-羟基咪达唑仑下游产品

4-羟基咪达唑仑文献

A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice.

Biochem. Pharmacol. 92(4) , 701-11, (2014)

The hepatic cytochrome P450 reductase null (HRN) mouse, which has no functional hepatic Cyp P450s, may represent a useful model for examining extra-hepatic P450-related oxidative metabolism. Here the ...

Systematic evaluation of commercially available ultra-high performance liquid chromatography columns for drug metabolite profiling: optimization of chromatographic peak capacity.

J. Chromatogr. A. 1374 , 122-33, (2014)

The present study investigated the practical use of modern ultra-high performance liquid chromatography (UHPLC) separation techniques for drug metabolite profiling, aiming to develop a widely applicab...

Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.

Xenobiotica 45(4) , 345-52, (2015)

1. The purpose of this study was to clarify species differences in the heteroactivation of CYP3A substrates by efavirenz, which is known from clinical studies to activate midazolam 1'-hydroxylation, a...

更多文献