尼柯霉素 Z
尼柯霉素 Z用途
尼柯霉素 Z名称
[ CAS 号 ]:
59456-70-1
[ 中文名 ]:
华光霉素
[ 英文名 ]:
Nikkomycin Z
[中文别名 ]:
[英文别名 ]:
- Nikkomycin Z
- MFCD00869648
尼柯霉素 Z生物活性
[ 描述 ]:
[ 相关类别 ]:
[参考文献]
尼柯霉素 Z物理化学性质
[ 密度 ]:
1.646 g/cm3
[ 分子式 ]:
C20H25N5O10
[ 分子量 ]:
495.44000
[ 精确质量 ]:
495.16000
[ PSA ]:
250.32000
[ 折射率 ]:
1.678
[ 储存条件 ]:
2-8°C,密封,干燥
尼柯霉素 Z毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- BA2928200
- CHEMICAL NAME :
- beta-D-Allofuranuronic acid, 5-((2-amino-4-hydroxy-4-(5-hydroxy-2-pyridinyl)-3-met hyl- 1-oxobutyl)amino)-1,5-dideoxy-1-(3,4-dihydro-2,4-diox o-1(2H)-pyrimidinyl)-, (2S-(2R*,3R*,4R*))-
- CAS REGISTRY NUMBER :
- 59456-70-1
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H25-N5-O10
- MOLECULAR WEIGHT :
- 495.50
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961- Volume(issue)/page/year: 44,1709,1980
尼柯霉素 Z安全信息
[ 符号 ]:
GHS07
[ 信号词 ]:
Warning
[ 危害声明 ]:
H315-H319-H335
[ 警示性声明 ]:
P261-P305 + P351 + P338
[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves
[ 危害码 (欧洲) ]:
Xi: Irritant;
[ 风险声明 (欧洲) ]:
R36/37/38
[ 安全声明 (欧洲) ]:
26-36
[ 危险品运输编码 ]:
NONH for all modes of transport
[ RTECS号 ]:
BA2928200
尼柯霉素 Z制备
1.由唐德轮枝锭霉菌S-9深层发酵,再经提取制得。工艺流程为:
砂土孢子→茄子瓶菌种→种子罐种子→发酵罐发酵→
板框压滤→滤液浓缩→喷雾干燥→调配→成品
尼柯霉素 Z文献
BMC Microbiol. 11 , 164, (2011)
sabR is a pleiotropic regulatory gene which has been shown to positively regulate the nikkomycin biosynthesis and negatively affect the sporulation of Streptomyces ansochromogenes. In this study, we i...
Reshuffling of Aspergillus fumigatus cell wall components chitin and β-glucan under the influence of caspofungin or nikkomycin Z alone or in combination.Antimicrob. Agents Chemother. 56 , 1595-1598, (2012)
Chitin and β-glucan are major cell wall components of Aspergillus spp. We investigated the antifungal activity of chitin synthesis inhibitors nikkomycin Z, polyoxin D, flufenoxuron, lufenuron, and tef...
Characterization of the PLP-dependent aminotransferase NikK from Streptomyces tendae and its putative role in nikkomycin biosynthesis.FEBS J. 278(21) , 4122-35, (2011)
As inhibitors of chitin synthase, nikkomycins have attracted interest as potential antibiotics. The biosynthetic pathway to these peptide nucleosides in Streptomyces tendae is only partially known. In...
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