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盐酸美普他酚

盐酸美普他酚用途

Meptazinol Hcl(WY-22811 Hcl) is a unique centrally active opioid analgesic.

盐酸美普他酚名称

[ CAS 号 ]:
59263-76-2

[ 中文名 ]:
盐酸美普他酚

[ 英文名 ]:
Meptazinol HCl

[中文别名 ]:

[英文别名 ]:

UNII:T62FQ4ZCPA
MEPTAZINOL HYDROCHLORIDE

盐酸美普他酚物理化学性质

[ 沸点 ]:
354.8ºC at 760 mmHg

[ 熔点 ]:
250-252ºC

[ 分子式 ]:
C₁₅H₂₄ClNO

[ 分子量 ]:
269.810

[ 闪点 ]:
160.6ºC

[ 精确质量 ]:
269.154633

[ PSA ]:
23.47000

[ LogP ]:
3.89560

[ 外观性状 ]:
白色固体

[ 储存条件 ]:
Desiccate at +4°C

[ 水溶解性 ]:
H2O: >10mg/mL

盐酸美普他酚MSDS

盐酸美普他酚毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SL4250000

CHEMICAL NAME :: Phenol, 3-(3-ethylhexahydro-1-methyl-1H-azepin-3-yl)-, hydrochloride

CAS REGISTRY NUMBER :: 59263-76-2

LAST UPDATED :: 199512

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C15-H23-N-O.Cl-H

MOLECULAR WEIGHT :: 269.85

WISWESSER LINE NOTATION :: T7NTJ A1 C2 CR CQ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1260 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 106 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 282 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 118 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4550 mg/kg/26W-I

TOXIC EFFECTS :: Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

REFERENCE :: GEPHDP General Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.6- 1975- Volume(issue)/page/year: 9,73,1978

盐酸美普他酚安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 危险品运输编码 ]:
NONH for all modes of transport

[ RTECS号 ]:
SL4250000

[ 海关编码 ]:
2942000000

盐酸美普他酚合成路线

盐酸美普他酚上下游产品

盐酸美普他酚上游产品

盐酸美普他酚下游产品

盐酸美普他酚海关

[ 海关编码 ]: 2942000000

盐酸美普他酚文献

Bis(9)-(-)-nor-meptazinol as a novel dual-binding AChEI potently ameliorates scopolamine-induced cognitive deficits in mice.

Pharmacol. Biochem. Behav. 104 , 138-43, (2013)

Alzheimer's disease (AD) is a multifaceted neurodegenerative disorder which is characterized by the progressive deterioration of cognition and the emergence of behavioral and psychological symptoms in...

Reflex activity caused by laryngoscopy and intubation is obtunded differently by meptazinol, nalbuphine and fentanyl.

Eur. J. Anaesthesiol. 24(1) , 53-8, (2007)

To evaluate the different potencies of several opioids in obtunding reflex mechanisms of laryngoscopy and intubation.Three groups of patients (each n = 25, ASA 1-2) undergoing elective plastic surgery...

Lack of sensitization during place conditioning in rats is consistent with the low abuse potential of tramadol.

Neurosci. Lett. 329(1) , 25-8, (2002)

Based on the recent finding that tramadol (TRAM) produces conditioned place preference (CPP) and dopamine release in the nucleus accumbens, it was suggested that the abuse liability of TRAM may be gre...

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