月桂氮酮

月桂氮酮用途

用途1：用作渗透剂，用于化妆品中各类膏霜及发用品；用作外用药物涂抹、按摩的促渗剂；用于农药，作为植物生长调节剂的促吸剂及杀菌、杀虫剂的促渗剂；此外，还可用于皮革及印染等领域的着色促进剂。
用途2：无色至微黄色澄清油状液体。
用途3：氮酮是一种新型高效、安全无毒的透皮吸收促进剂，对亲水和亲油药物均有明显的透皮助渗作用。可广泛用于医药、化妆品、农药、气雾剂、印染及石油勘探等行业中，本品具有渗透作用强、无色、无味、无毒、无刺激性等优点。
用途4：用作高效皮肤渗透促进剂，用于外用药、化妆品及作表面活性剂。

月桂氮酮名称

[ CAS 号 ]:
59227-89-3

[ 中文名 ]:
氮酮

[ 英文名 ]:
Laurocapram

[中文别名 ]:

[英文别名 ]:

1-dodecyl-hexahydro-azepin-2-one
MFCD00190580
2H-Azepin-2-one, 1-dodecylhexahydro-
tranzone
acecloguanosine
EINECS 261-668-9
1-Dodecylazepan-2-one
Lauocapram
1 dodecylperhydroazepin 2 one
AZONE

月桂氮酮生物活性

[ 描述 ]:

Laurocapram 是一种吸收促进剂,对于亲脂性和亲水性物质都是最有效的吸收剂之一。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. López-Cervantes M, et al. Chemical enhancers for the absorption of substances through the skin: Laurocapram and its derivatives. Drug Dev Ind Pharm. 2006 Mar;32(3):267-86.

月桂氮酮物理化学性质

[ 密度 ]:
0.9±0.1 g/cm3

[ 沸点 ]:
404.9±14.0 °C at 760 mmHg

[ 熔点 ]:
-7ºC

[ 分子式 ]:
C₁₈H₃₅NO

[ 分子量 ]:
281.477

[ 闪点 ]:
165.2±10.7 °C

[ 精确质量 ]:
281.271851

[ PSA ]:
20.31000

[ LogP ]:
6.57

[ 外观性状 ]:
无色或淡黄色透明液体

[ 蒸汽压 ]:
0.0±0.9 mmHg at 25°C

[ 折射率 ]:
1.466

[ 储存条件 ]:
室温

[ 水溶解性 ]:
水溶性：不溶；水溶解度：0.171 mg/l 25 °C

月桂氮酮MSDS

详细MSDS(安全技术说明书)

月桂氮酮毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: CM3995000

CHEMICAL NAME :: 2H-Azepin-2-one, hexahydro-N-lauryl-

CAS REGISTRY NUMBER :: 59227-89-3

BEILSTEIN REFERENCE NO. :: 0167211

LAST UPDATED :: 199806

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C18-H35-N-O

MOLECULAR WEIGHT :: 281.54

WISWESSER LINE NOTATION :: T7NVTJ A12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4882359

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARDEAC Archives of Dermatology. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.82- 1960- Volume(issue)/page/year: 118,474,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DDIPD8 Drug Development and Industrial Pharmacy. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.3- 1977- Volume(issue)/page/year: 9,725,1983

月桂氮酮安全信息

[ 危害码 (欧洲) ]:
Xi

[ 海关编码 ]:
2933790090

月桂氮酮合成路线

详细合成路线

月桂氮酮上下游产品

月桂氮酮上游产品

月桂氮酮下游产品

月桂氮酮海关

[ 海关编码 ]: 2933790090

[ 中文概述 ]:
2933790090 其他内酰胺. 增值税率:17.0% 退税率:9.0% 监管条件:无最惠国关税:9.0% 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%