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TBBz

TBBz用途

4,5,6,7-四溴苯并咪唑是一种选择性和ATP竞争性CK2(酪蛋白激酶2)抑制剂[1]。

TBBz名称

[ CAS 号 ]:
577779-57-8

[ 英文名 ]:
TBBz

[英文别名 ]:

4,5,6,7-Tetrabrom-1H-benzimidazol
4,5,6,7-tetrabromobenzimidazole
2oxy
TBBz

TBBz生物活性

[ 描述 ]:

4,5,6,7-四溴苯并咪唑是一种选择性和ATP竞争性CK2(酪蛋白激酶2)抑制剂[1]。

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 细胞周期/DNA损伤 >> 酪蛋白激酶

信号通路 >> 干细胞及 Wnt 通路 >> 酪蛋白激酶

[ 靶点 ]

CK2

[参考文献]

[1]. Zień P, et al. Selectivity of 4,5,6,7-tetrabromobenzimidazole as an ATP-competitive potent inhibitor of protein kinase CK2 from various sources. Biochem Biophys Res Commun. 2003 Jun 20;306(1):129-33.

TBBz物理化学性质

[ 熔点 ]:
330-332ºC

[ 分子式 ]:
C₇H₂Br₄N₂

[ 分子量 ]:
433.72000

[ 精确质量 ]:
429.69500

[ PSA ]:
28.68000

[ LogP ]:
4.61290

[ 储存条件 ]:
-20°C，密闭，干燥

TBBzMSDS

详细MSDS(安全技术说明书)

TBBz安全信息

[ 符号 ]:

GHS06

[ 信号词 ]:
Danger

[ 危害声明 ]:
H301-H319

[ 警示性声明 ]:
P301 + P310-P305 + P351 + P338

[ 个人防护装备 ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ 危险品运输编码 ]:
UN 2811 6.1 / PGIII

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TBBz文献

An unbiased evaluation of CK2 inhibitors by chemoproteomics: characterization of inhibitor effects on CK2 and identification of novel inhibitor targets.

Mol. Cell. Proteomics 7(6) , 1077-88, (2008)

Recently protein kinases have emerged as some of the most promising drug targets; and therefore, pharmaceutical strategies have been developed to inhibit kinases in the treatment of a variety of disea...

Casein kinase II contributes to the synergistic effects of BMP7 and BDNF on Smad 1/5/8 phosphorylation in septal neurons under hypoglycemic stress.

J. Neurochem. 109(3) , 733-43, (2009)

The combination of bone morphogenetic protein 7 (BMP7) and neurotrophins (e.g. brain-derived neurotrophic factor, BDNF) protects septal neurons during hypoglycemic stress. We investigated the signalin...

Characterizing the convergence of protein kinase CK2 and caspase-3 reveals isoform-specific phosphorylation of caspase-3 by CK2α': implications for pathological roles of CK2 in promoting cancer cell survival.

Oncotarget 4 , 560-71, (2013)

Protein kinase CK2 has emerged as a promising candidate for the treatment of a number of cancers. This enzyme is comprised of two catalytic subunits (CK2 and/or CK2α') that form complexes with homodim...

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