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秦皮素

秦皮素用途

Fraxetin 是从 Cortex Fraxini 中分离出来的。 Fraxetin 具有抗肿瘤,抗氧化作用和抗炎作用。 Fraxetin 诱导细胞凋亡 (apoptosis)。

秦皮素名称

[ CAS 号 ]:
574-84-5

[ 中文名 ]:
秦皮素

[ 英文名 ]:
Fraxetin

[中文别名 ]:

[英文别名 ]:

Coumarin, 7,8-dihydroxy-6-methoxy-
EINECS 209-376-2
6-methoxy-7,8-dihydroxycoumarin
7,8-Dihydroxy-6-methoxy-2H-chromen-2-one
2H-1-Benzopyran-2-one,7,8-dihydroxy-6-methoxy
7,8-Dihydroxy-6-methoxycoumarin
2H-1-Benzopyran-2-one, 7,8-dihydroxy-6-methoxy-
7,8-dihydroxy-6-methoxy-benzopyran-2-one
7,8-Dihydroxy-6-methoxy-2H-1-benzopyran-2-one
Fraxetin

秦皮素生物活性

[ 描述 ]:

Fraxetin 是从 Cortex Fraxini 中分离出来的。 Fraxetin 具有抗肿瘤,抗氧化作用和抗炎作用。 Fraxetin 诱导细胞凋亡 (apoptosis)。

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

[参考文献]

[1]. Chen X, et al. The therapeutic effect of fraxetin on ethanol-induced hepatic fibrosis by enhancing ethanol metabolism, inhibiting oxidative stress and modulating inflammatory mediators in rats. Int Immunopharmacol. 2018 Mar;56:98-104.

[2]. Liu G, et al. Effect of fraxetin on proliferation and apoptosis in breast cancer cells. Oncol Lett. 2017 Dec;14(6):7374-7378.

秦皮素物理化学性质

[ 密度 ]:
1.5±0.1 g/cm3

[ 沸点 ]:
472.0±45.0 °C at 760 mmHg

[ 熔点 ]:
230-232°C

[ 分子式 ]:
C₁₀H₈O₅

[ 分子量 ]:
208.167

[ 闪点 ]:
196.0±22.2 °C

[ 精确质量 ]:
208.037170

[ PSA ]:
79.90000

[ LogP ]:
0.59

[ 外观性状 ]:
淡黄色结晶片

[ 蒸汽压 ]:
0.0±1.2 mmHg at 25°C

[ 折射率 ]:
1.648

[ 储存条件 ]:
2~8°C

秦皮素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302 + H312 + H332-H315-H319-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn: Harmful;

[ 风险声明 (欧洲) ]:
R20/21/22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2932209090

秦皮素上下游产品

秦皮素上游产品

秦皮素下游产品

秦皮素海关

[ 海关编码 ]: 2932209090

[ 中文概述 ]:
2932209090. 其他内酯. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

秦皮素文献

[Studies on chemical constituents from stem barks of Fraxinus paxiana].

Zhongguo Zhong Yao Za Zhi 33(16) , 1990-3, (2008)

To investigate the chemical constituents of Fraxinus paxiana.The chemical constituents were isolated and purified by chromatographic techniques and the structures of the compounds were identified with...

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.

Biochimie 95(10) , 1848-54, (2013)

Epidemiological studies have demonstrated that the diabetes mellitus is a serious health burden for both governments and healthcare providers. The present study was hypothesized to evaluate the antihy...

[Coumarins from branch of Fraxinus sieboldiana and their antioxidative activity].

Zhongguo Zhong Yao Za Zhi 33(14) , 1708-10, (2008)

To investigate the chemical constituents from the branch of Fraxinus sieboldiana, and evaluate their antioxidative activity.The chemical constituents were isolated and purified by chromatographic tech...

更多文献

秦皮素