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6-疏基嘌呤核苷

6-疏基嘌呤核苷用途

6-​Thioinosine (6TI) 是一种嘌呤抗代谢物,为抗脂肪形成剂,能够降低 PPAR γ 和 C/EBPα 及其目标基因 LPL,CD36,aP2 和 LXRα 的 mRNA 水平。

6-疏基嘌呤核苷名称

[ CAS 号 ]:
574-25-4

[ 中文名 ]:
6-疏基嘌呤核苷

[ 英文名 ]:
6-mercaptopurine riboside

[中文别名 ]:

[英文别名 ]:

6-疏基嘌呤核苷生物活性

[ 描述 ]:

6-​Thioinosine (6TI) 是一种嘌呤抗代谢物,为抗脂肪形成剂,能够降低 PPAR γ 和 C/EBPα 及其目标基因 LPL,CD36,aP2 和 LXRα 的 mRNA 水平。

[ 相关类别 ]:

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物
研究领域 >> 代谢疾病

[参考文献]

[1]. Lee J, et al. Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPAR gamma through JNK-dependent upregulation of iNOS. Cell Mol Life Sci. 2010 Feb;67(3):467-81.

[2]. Neubert D, et al. Interference of 6-mercaptopurine riboside, 6-methylmercaptopurine riboside and azathioprine with the morphogenetic differentiation of mouse extremities in vivo and in organ culture. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):93-105.

6-疏基嘌呤核苷物理化学性质

[ 密度 ]:
2.02g/cm3

[ 沸点 ]:
714.7ºC at 760mmHg

[ 熔点 ]:
220-223ºC(lit.)

[ 分子式 ]:
C10H12N4O4S

[ 分子量 ]:
284.29200

[ 闪点 ]:
386ºC

[ 精确质量 ]:
284.05800

[ PSA ]:
148.51000

[ 折射率 ]:
1.6270 (estimate)

[ 储存条件 ]:
-20°C

[ 稳定性 ]:
Store in Cool Dry Place

6-疏基嘌呤核苷MSDS

详细MSDS(安全技术说明书)

6-疏基嘌呤核苷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UP0710000
CHEMICAL NAME :
9H-Purine-6-thiol, 9-beta-D-ribofuranosyl-
CAS REGISTRY NUMBER :
574-25-4
LAST UPDATED :
199606
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C10-H12-N4-O4-S
MOLECULAR WEIGHT :
284.32
WISWESSER LINE NOTATION :
T56 BN DN FN HNJ ISH D- BT5OTJ CQ DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
900 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1310 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1270 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1840 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
350 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - skin and skin appendages Reproductive - Specific Developmental Abnormalities - homeostasis
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
175 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
42 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
87500 ug/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
21 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - skin and skin appendages
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
42 mg/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
87500 ug/kg
SEX/DURATION :
female 9-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - homeostasis

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
200 ug/plate
REFERENCE :
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970- Volume(issue)/page/year: 44,96,1985

6-疏基嘌呤核苷安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
S22;S24/25

[ WGK德国 ]:
3

[ RTECS号 ]:
UP0710000

6-疏基嘌呤核苷合成路线

详细合成路线

6-疏基嘌呤核苷上下游产品

6-疏基嘌呤核苷上游产品

6-疏基嘌呤核苷下游产品

推荐生产厂家/供应商：

公司名：上海吉至生化科技有限公司

区域：上海市奉贤区

价格：
￥4308.0/10g ￥2578.0/5g ￥8358.0/25g

联系人：刘佳

产品详情：6-巯基嘌呤-9-D-核苷

公司名：上海创赛科技有限公司

区域：上海市嘉定区

价格：
￥120.0/50mg ￥363.0/250mg

联系人：夏言

产品详情：[Perfemiker]6-疏基嘌呤核苷,98%

公司名：武汉敬康恩生物医药科技有限公司

区域：武汉市东西湖区

价格：
￥需询单/1g

联系人：周经理

产品详情：6-MERCAPTOPURINE RIBOSIDE

公司名：武汉壹加壹生物科技有限公司

区域：武汉市江夏区

价格：
￥需询单/1mg

联系人：刘经理

产品详情：6-疏基嘌呤核苷

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标题：6-疏基嘌呤核苷_MSDS_用途_密度_CAS号【574-25-4】_化源网 地址：https://www.chemsrc.com/amp/cas/574-25-4_756849.html