N-叔丁氧羰基-1,2-乙二胺

N-叔丁氧羰基-1,2-乙二胺用途

PROTAC Linker 22 是一种 PROTAC 连接桥,属于 alkyl chain类。PROTAC Linker 22 可用于合成一系列 PROTAC 分子。PROTAC 分子含有两个通过连接桥连接的不同配体; 一种是 E3 泛素连接酶配体,另一种是靶蛋白配体。PROTAC 利用细胞内泛素-蛋白酶体系统选择性降解靶蛋白。

N-叔丁氧羰基-1,2-乙二胺名称

[ CAS 号 ]:
57260-73-8

[ 中文名 ]:
N-叔丁氧羰基-1,2-乙二胺

[ 英文名 ]:
N-Boc-Ethylenediamine

[中文别名 ]:

[英文别名 ]:

N-tert-Boc-ethylenediamine
tert-butyl-(2-aminoethyl)carbamat
tert-butyl (2-aminoethyl)carbamate
2-Methyl-2-propanyl (2-aminoethyl)carbamate
tert-butyl N-(2-aminoethyl)carbamate
MFCD00191871
N-(tert-Butoxycarbonyl)-1,2-diaminoethane

N-叔丁氧羰基-1,2-乙二胺生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC Linker

[ 靶点 ]

Alkyl-Chain

[参考文献]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

N-叔丁氧羰基-1,2-乙二胺物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
252.8±23.0 °C at 760 mmHg

[ 分子式 ]:
C₇H₁₆N₂O₂

[ 分子量 ]:
160.214

[ 闪点 ]:
106.7±22.6 °C

[ 精确质量 ]:
160.121185

[ PSA ]:
64.35000

[ LogP ]:
0.54

[ 外观性状 ]:
无色至淡黄色

[ 蒸汽压 ]:
0.0±0.5 mmHg at 25°C

[ 折射率 ]:
1.454

[ 储存条件 ]:
Refrigerator (+4°C)

N-叔丁氧羰基-1,2-乙二胺MSDS

N-叔丁氧羰基-1,2-乙二胺安全信息

[ 符号 ]:

GHS05

[ 信号词 ]:
Danger

[ 危害声明 ]:
H314

[ 警示性声明 ]:
P280-P305 + P351 + P338-P310

[ 个人防护装备 ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ 危害码 (欧洲) ]:
C:Corrosive;

[ 风险声明 (欧洲) ]:
R34

[ 安全声明 (欧洲) ]:
S26-S36/37/39-S45

[ 危险品运输编码 ]:
UN 2735 8/PG 3

[ WGK德国 ]:
3

[ 包装等级 ]:
III

[ 危险类别 ]:
8

[ 海关编码 ]:
2924199090

N-叔丁氧羰基-1,2-乙二胺合成路线

N-叔丁氧羰基-1,2-乙二胺上下游产品

N-叔丁氧羰基-1,2-乙二胺上游产品

N-叔丁氧羰基-1,2-乙二胺下游产品

N-叔丁氧羰基-1,2-乙二胺海关

[ 海关编码 ]: 2924199090

[ 中文概述 ]:
2924199090. 其他无环酰胺（包括无环氨基甲酸酯)(包括其衍生物及盐）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 包装

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

N-叔丁氧羰基-1,2-乙二胺文献

Synthesis and antitumor properties of an anthraquinone bisubstituted by the copper chelating peptide Gly-Gly-L-His.

J. Med. Chem. 36 , 2084, (1993)

A new molecule 4 [(GGH-DAE)2DHQ] associating the 1,4,5,8-tetrahydroxyanthraquinone ring (DHQ) of the antitumor drug mitoxantrone (2), two diaminoethylene chains (DAE), and the metal-chelating peptide ...

A convenient and scalable synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride. Key intermediates for peptide nucleic acid synthesis.

J. Org. Chem. 68 , 1630, (2003)

An improved synthesis of ethyl N-[(2-Boc-amino)ethyl]glycinate and its hydrochloride salt is reported. The synthesis is based on the reductive alkylation of Boc-ethylenediamine with ethyl glyoxylate h...

Synthesis and evaluation of some nitrobenzenesulfonamides containing nitroisopropyl and (ureidooxy)methyl groups as novel hypoxic cell selective cytotoxic agents.

J. Med. Chem. 34 , 3132, (1991)

Basic nitrobenzenesulfonamides containing nitroisopropyl and (ureidooxy)methyl groups were prepared and evaluated as novel hypoxic cell selective cytotoxic agents. In vitro, N-(2-aminoethyl)-N-methyl-...

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