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甲基立枯磷

甲基立枯磷用途

Tolclofos-methyl是一种广谱内吸性杀菌剂, 用于防治引起种子腐烂和幼苗摧残的土传和种传真菌病原体。

甲基立枯磷名称

[ CAS 号 ]:
57018-04-9

[ 中文名 ]:
甲基立枯磷

[ 英文名 ]:
Tolclofos-methyl

[中文别名 ]:

[英文别名 ]:

EINECS 260-515-3
MFCD00078741
Tolclofos-methyl

甲基立枯磷生物活性

[ 描述 ]:

Tolclofos-methyl是一种广谱内吸性杀菌剂, 用于防治引起种子腐烂和幼苗摧残的土传和种传真菌病原体。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[相关活性小分子]

甲基立枯磷物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
338.5±52.0 °C at 760 mmHg

[ 熔点 ]:
78-80°C

[ 分子式 ]:
C₉H₁₁Cl₂O₃PS

[ 分子量 ]:
301.127

[ 闪点 ]:
158.5±30.7 °C

[ 精确质量 ]:
299.954346

[ PSA ]:
69.59000

[ LogP ]:
4.03

[ 蒸汽压 ]:
0.0±0.7 mmHg at 25°C

[ 折射率 ]:
1.563

[ 储存条件 ]:
库房通风低温干燥,与氧化剂、碱类、食品添加剂分开存放

甲基立枯磷MSDS

甲基立枯磷毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TF0460000

CHEMICAL NAME :: Phosphorothioic acid, O-(2,6-dichloro-p-tolyl) O,O-dimethyl ester

CAS REGISTRY NUMBER :: 57018-04-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C9-H11-Cl2-O3-P-S

MOLECULAR WEIGHT :: 301.13

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094) Volume(issue)/page/year: -,C265,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (41),21,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4900 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A508,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (41),21,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A508,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (41),21,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A508,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPIFAN Japan Pesticide Information. (Japan Plant Protection Assoc., 1-43-11, Komagome, Toshima-ku, Tokyo 170, Japan) No.1-61, 1969-92. For publisher information, see AGJAEP. Volume(issue)/page/year: (41),21,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 8,810,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - duck

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968- Volume(issue)/page/year: 9,826,1991

甲基立枯磷安全信息

[ 符号 ]:

GHS07, GHS09

[ 信号词 ]:
Warning

[ 危害声明 ]:
H317-H410

[ 警示性声明 ]:
P273-P280-P501

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi,N

[ 风险声明 (欧洲) ]:
43-50/53

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ RTECS号 ]:
TF0460000

[ 海关编码 ]:
3808929029

甲基立枯磷合成路线

甲基立枯磷上下游产品

甲基立枯磷上游产品

甲基立枯磷下游产品

甲基立枯磷制备

以对甲酚为原料，用催化氯化法制得2，6-二氯-4-甲基苯酚。继而以苄基三乙基溴化铵（TEBA）为催化剂，将0.105mol二氯对甲酚与O，O-二甲基硫代磷酰氯作用，反应温度60～70℃，时间2h，溶剂甲苯，缚酸剂碳酸钾。反应结束后经后处理得甲基立枯磷29.8g，收率91.5%，含量92.5%。
O，O-二甲基硫代磷酰氯与2，6-二氯-4-甲基苯酚缩合的方法很多，如在铜粉存在下，加入20%氢氧化钠水溶液，于50℃缩合反应30min，保温2h，制得甲基立枯磷；也可在有机溶剂中进行，不需将酚变为酚钠，溶剂为二甲苯，缚酸剂碳酸钾，催化剂三乙胺或铜粉，甲基立枯磷的收率90%。

甲基立枯磷海关

[ 海关编码 ]: 3808929029