三氯叔丁醇

三氯叔丁醇用途

Chlorobutanol 是一种药物防腐剂,具有镇静催眠作用。Chlorobutanol 对多种革兰氏阳性和革兰氏阴性细菌 ( Gram-positive and Gram-negative bacteria) 以及几种霉菌孢子和真菌 (fungi) 具有抗性。

三氯叔丁醇名称

[ CAS 号 ]:
57-15-8

[ 中文名 ]:
三氯叔丁醇

[ 英文名 ]:
Chlorobutanol

[中文别名 ]:

[英文别名 ]:

tert-Trichlorobutyl alcohol
MFCD00004461
1,1,1-Trichloro-2-methylpropan-2-ol
2-Propanol, 1,1,1-trichloro-2-methyl-
chlorobutanol
1,1,1-Trichloro-2-methyl-2-propanol
Trichloro-tert-butanol
EINECS 200-317-6
Trichloro-t-butyl alcohol

三氯叔丁醇生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 真菌

研究领域 >> 神经疾病

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Smoak IW, et al. Chlorobutanol: maternal serum levels and placental transfer in the mouse. Vet Hum Toxicol. 1997 Oct;39(5):287-90.

[2]. Friesen WT, et al. The antibacterial stability of chlorobutanol stored in polyethylene bottles. Am J Hosp Pharm. 1971 Jul;28(7):507-12.

三氯叔丁醇物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
167.0±0.0 °C at 760 mmHg

[ 熔点 ]:
~78 °C

[ 分子式 ]:
C₄H₇Cl₃O

[ 分子量 ]:
177.457

[ 闪点 ]:
61.8±25.9 °C

[ 精确质量 ]:
175.956253

[ PSA ]:
49.69000

[ LogP ]:
2.07

[ 蒸汽压 ]:
0.6±0.6 mmHg at 25°C

[ 折射率 ]:
1.491

[ 储存条件 ]:
库房通风低温干燥,与氧化剂分开存放

[ 稳定性 ]:
Stable. Generates toxic fumes on combustion.

三氯叔丁醇MSDS

三氯叔丁醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UC0175000

CHEMICAL NAME :: 2-Propanol, 1,1,1-trichloro-2-methyl-

CAS REGISTRY NUMBER :: 57-15-8

BEILSTEIN REFERENCE NO. :: 0878167

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C4-H7-Cl3-O

MOLECULAR WEIGHT :: 177.46

WISWESSER LINE NOTATION :: QX1&1&XGGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 238 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 213 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 20 umol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 90,91,1981 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - T1007 No. of Facilities: 798 (estimated) No. of Industries: 3 No. of Occupations: 13 No. of Employees: 25038 (estimated) No. of Female Employees: 21000 (estimated)

三氯叔丁醇安全信息

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22:Harmful if swallowed. R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S26-S36/37/39

[ WGK德国 ]:
3

[ 海关编码 ]:
2905143000

三氯叔丁醇合成路线

三氯叔丁醇上下游产品

三氯叔丁醇上游产品

三氯叔丁醇下游产品

三氯叔丁醇制备

1.由丙酮与氯仿反应而得：将氯仿、丙酮按1：0.5的配料比加入反应锅内，冷至8℃，搅拌下缓缓加入氢氧化钾，控制温度不超过15℃。加完后维持同温搅拌2h，放料、过滤，滤液浓缩至没有馏液滴出为止。停止加热，降温至25℃加入冰水，搅拌，析出结晶、离心结晶、离心分离，滤饼用蒸馏水洗涤至无氯离子为止。在60-65℃下干燥约2h，过筛，包装。收率为56%（以氯仿计）。原料消耗定额：氯仿1247kg/t、丙酮1688kg/t、氢氧化钾285kg/t。

三氯叔丁醇海关

[ 海关编码 ]: 2905143000