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伪金丝桃素

伪金丝桃素用途

Pseudohypericin 及其同系物 Hypericin 是金丝桃属植物中主要的羟基菲咯啉酮类化合物。Pseudohypericin 具有抗 HIV 病毒活性。

伪金丝桃素名称

[ CAS 号 ]:
55954-61-5

[ 中文名 ]:
伪金丝桃素

[ 英文名 ]:
Pseudohypericin

[中文别名 ]:

假金丝桃素

[英文别名 ]:

Psuedohypericin
C30H16O9
BIDD:PXR0086
MFCD00133794

伪金丝桃素生物活性

[ 描述 ]:

Pseudohypericin 及其同系物 Hypericin 是金丝桃属植物中主要的羟基菲咯啉酮类化合物。Pseudohypericin 具有抗 HIV 病毒活性。

[ 相关类别 ]:

信号通路 >> 抗感染 >> HIV

研究领域 >> 感染

[体外研究]

假金丝桃素具有抗逆转录病毒活性[1]。

[参考文献]

[1]. Lavie G, et al. Studies of the mechanisms of action of the antiretroviral agents hypericin and pseudohypericin. Proc Natl Acad Sci U S A. 1989 Aug;86(15):5963-7.

[2]. Zheng X, et al. Apoptosis of THP-1 Macrophages Induced by Pseudohypericin-Mediated Sonodynamic Therapy Through the Mitochondria-Caspase Pathway. Cell Physiol Biochem. 2016;38(2):545-57.

伪金丝桃素物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
994.7±65.0 °C at 760 mmHg

[ 分子式 ]:
C₃₀H₁₆O₉

[ 分子量 ]:
520.443

[ 闪点 ]:
569.2±30.8 °C

[ 精确质量 ]:
520.079407

[ PSA ]:
175.75000

[ LogP ]:
6.75

[ 蒸汽压 ]:
0.0±0.3 mmHg at 25°C

[ 折射率 ]:
2.169

[ 储存条件 ]:
2-8°C

伪金丝桃素MSDS

详细MSDS(安全技术说明书)

伪金丝桃素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 危害码 (欧洲) ]:
Xi

[ 风险声明 (欧洲) ]:
22

[ 安全声明 (欧洲) ]:
22-36

[ 危险品运输编码 ]:
NONH for all modes of transport

伪金丝桃素文献

Hypericum perforatum: pharmacokinetic, mechanism of action, tolerability, and clinical drug-drug interactions.

Phytother Res. 28(5) , 643-55, (2014)

Hypericum perforatum (HP) belongs to the Hypericaceae family and is one of the oldest used and most extensively investigated medicinal herbs. The medicinal form comprises the leaves and flowering tops...

The main components of St John's Wort inhibit low-density lipoprotein atherogenic modification: a beneficial "side effect" of an OTC antidepressant drug?

Free Radic. Res. 41(2) , 234-41, (2007)

Hypericin and pseudohypericin are polycyclic-phenolic structurally related compounds found in Hypericum perforatum L. (St John's wort). As hypericin has been found to bind to LDL one may assume that i...

Rapid and efficient purification of naphthodianthrones from St. John's wort extract by using liquid-liquid extraction and SEC.

J. Sep. Sci. 32(9) , 1374-82, (2009)

Hypericin and pseudohypericin, the main naphthodianthrones present in Hypericum species are among the most promising natural products, but the research concerning their biological activities is hinder...

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