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N-甲基-N-炔丙基苯甲胺

N-甲基-N-炔丙基苯甲胺用途

Pargyline是一个不可逆的非选择性单胺氧化酶 (MAO) 抑制剂的药物 (作用于MAO-A和MAO-B时,IC50 分别是11.52 nM和8.2 nM)。

N-甲基-N-炔丙基苯甲胺名称

[ CAS 号 ]:
555-57-7

[ 中文名 ]:
优降宁

[ 英文名 ]:
Pargyline

[中文别名 ]:

[英文别名 ]:

EINECS 209-101-6
N-benzyl-N-methylprop-2-yn-1-amine
MFCD00008576
Pargyline

N-甲基-N-炔丙基苯甲胺生物活性

[ 描述 ]:

Pargyline是一个不可逆的非选择性单胺氧化酶 (MAO) 抑制剂的药物 (作用于MAO-A和MAO-B时,IC50 分别是11.52 nM和8.2 nM)。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 单胺氧化酶

研究领域 >> 神经疾病

[相关活性小分子]

N-甲基-N-炔丙基苯甲胺物理化学性质

[ 密度 ]:
0.94

[ 沸点 ]:
86-88ºC(4 torr)

[ 熔点 ]:
156 - 160ºC

[ 分子式 ]:
C₁₁H₁₃N

[ 分子量 ]:
159.22800

[ 闪点 ]:
83ºC

[ 精确质量 ]:
159.10500

[ PSA ]:
3.24000

[ LogP ]:
1.75160

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 折射率 ]:
n20/D 1.522(lit.)

[ 储存条件 ]:
存放于惰性气体之中;避免空气

N-甲基-N-炔丙基苯甲胺MSDS

详细MSDS(安全技术说明书)

N-甲基-N-炔丙基苯甲胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DP6475000

CHEMICAL NAME :: Benzylamine, N-methyl-N-2-propynyl-

CAS REGISTRY NUMBER :: 555-57-7

BEILSTEIN REFERENCE NO. :: 1938132

LAST UPDATED :: 199612

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C11-H13-N

MOLECULAR WEIGHT :: 159.25

WISWESSER LINE NOTATION :: 1UU2N1&1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 8750 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Sense Organs and Special Senses (Eye) - lacrimation Lungs, Thorax, or Respiration - other changes

REFERENCE :: 34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969 Volume(issue)/page/year: -,452,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,913,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 680 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 14,913,1971

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 290 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 22,367,1967

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 17,369,1968

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 56 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02420 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 180 mg/kg

SEX/DURATION :: male 12 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Implant

DOSE :: 100 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 138 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intratesticular

DOSE :: 200 mg/kg

SEX/DURATION :: male 21 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands

REFERENCE :: FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 27,1326,1976

N-甲基-N-炔丙基苯甲胺安全信息

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S23

[ 危险品运输编码 ]:
UN 2810 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
DP6475000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

N-甲基-N-炔丙基苯甲胺合成路线

详细合成路线

N-甲基-N-炔丙基苯甲胺上下游产品

N-甲基-N-炔丙基苯甲胺上游产品

N-甲基-N-炔丙基苯甲胺下游产品

N-甲基-N-炔丙基苯甲胺制备

由甲基苄胺与氯丙炔缩合，再用盐酸成盐而得。