延胡索酸泰妙菌素

延胡索酸泰妙菌素用途

Tiamulin (fumarate) 是一类二萜兽药,广泛用于控制猪的传染疾病,包括猪痢疾和地方性肺炎等。

延胡索酸泰妙菌素作用

泰妙菌素是属于截短侧耳素类的一种抑菌性抗生素，但在非常高的浓度下对敏感菌具有杀菌作用。与大环内酯类抗生素一样，泰妙菌素也是通过与核糖体50S亚单位结合，从而抑制细菌蛋白质的合成。
泰妙菌素对包括大多数葡萄球菌、链球菌（D群链球菌除外）在内的许多革兰氏阳性菌具有良好的抗菌活性，对支原体和猪痢疾密螺旋体也有较好的抗菌活性。除对胸膜肺炎放线杆菌、一些大肠杆菌和克雷伯菌的某些菌株有一定作用外，对革兰氏阴性菌的抗菌活性非常弱。
泰妙菌素主要用于治疗猪由敏感的胸膜肺炎放线杆菌引起的肺炎、密螺旋体性痢疾，以及鸡慢性呼吸道病。

延胡索酸泰妙菌素名称

[ CAS 号 ]:
55297-96-6

[ 中文名 ]:
延胡索酸泰妙菌素

[ 英文名 ]:
Tiamulin Fumarate

[中文别名 ]:

硫粘菌素

[英文别名 ]:

MFCD00145407
Tiamulin fumarate
EINECS 259-581-6
Tiamulin (fumarate)

延胡索酸泰妙菌素生物活性

[ 描述 ]:

Tiamulin (fumarate) 是一类二萜兽药,广泛用于控制猪的传染疾病,包括猪痢疾和地方性肺炎等。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[参考文献]

[1]. Noa M, et al. Tiamulin-nitrovin interaction in pigs: a case report and experimental reproduction. Vet Hum Toxicol. 2000 Oct;42(5):286-8.

[2]. Dreyfuss J, et al. Metabolism of tritium- and carbon-14-labeled tiamulin in dogs, rats, and pigs. J Antibiot (Tokyo). 1979 May;32(5):496-503.

[3]. Islam KM, et al. The activity and compatibility of the antibiotic tiamulin with other drugs in poultry medicine--A review. Poult Sci. 2009 Nov;88(11):2353-9.

[相关活性小分子]

延胡索酸泰妙菌素物理化学性质

[ 沸点 ]:
563ºCat 760 mmHg

[ 熔点 ]:
147-148°C

[ 分子式 ]:
C₃₂H₅₁NO₈S

[ 分子量 ]:
609.814

[ 闪点 ]:
294.3ºC

[ 精确质量 ]:
609.333557

[ PSA ]:
166.74000

[ LogP ]:
4.67970

[ 外观性状 ]:
粉末

[ 储存条件 ]:
2-8°C

延胡索酸泰妙菌素毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AG9560000

CAS REGISTRY NUMBER :: 55297-96-6

LAST UPDATED :: 199603

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C28-H47-N-O4-S.C4-H4-O4

MOLECULAR WEIGHT :: 609.90

WISWESSER LINE NOTATION :: L586/EN 2AE N EXTJ F1 GQ H1U1 H1 JOV1S2N2&2 K1 &QV1U1VQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 841 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 7,507,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 521 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 7,507,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 812 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 7,507,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 1860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 7,507,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Bird - chicken

DOSE/DURATION :: 270 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 7,507,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - turkey

DOSE/DURATION :: 1345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 7,507,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Bird - turkey

DOSE/DURATION :: 409 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 7,507,1975

延胡索酸泰妙菌素安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302

[ 警示性声明 ]:
P301 + P312 + P330

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
R22

[ 安全声明 (欧洲) ]:
S36

[ 危险品运输编码 ]:
UN2811 6.1/PG 3

[ RTECS号 ]:
AG9560000

[ 海关编码 ]:
2942000000

延胡索酸泰妙菌素海关

[ 海关编码 ]: 2942000000

延胡索酸泰妙菌素文献

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Vet. Microbiol. 172(1-2) , 223-9, (2014)

Brachyspira hyodysenteriae, the causative agent of swine dysentery, is responsible for severe mucohaemorrhagic colitis with considerable financial loss to worldwide swine production. Antimicrobial res...

[Effect of different compatibility of tetramethylpyrazine on its pharmacokinetics in vivo].

Zhongguo Zhong Yao Za Zhi 37(9) , 1311-4, (2012)

To study the pharmacokinetics of single administration and different compatibility of tetramethylpyrazine (TMP) in rats.Thirty two Sprague-Dawley rats were randomly divided into 4 groups: the TMP (30 ...

Design, synthesis, and antibacterial activity of novel pleuromutilin derivatives bearing an amino thiazolyl ring.

Arch. Pharm. (Weinheim) 345(8) , 638-46, (2012)

A series of novel pleuromutilin derivatives containing the amino thiazolyl ring were designed, synthesized, and evaluated for their antibacterial activities in vitro against Gram-positive clinical bac...

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