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阿苯达唑

阿苯达唑用途

Albendazole属于苯并咪唑类化合物,可抗蠕虫感染。

阿苯达唑名称

[ CAS 号 ]:
54965-21-8

[ 中文名 ]:
阿苯达唑

[ 英文名 ]:
Albendazole

[中文别名 ]:

[英文别名 ]:

SKF62979
Bilutac
MFCD00083232
ALBEN
Atasol
SK&F-62979
ZENTEL
SK&F 62979
ALBENZA
EINECS 259-414-7

阿苯达唑生物活性

[ 描述 ]:

Albendazole属于苯并咪唑类化合物,可抗蠕虫感染。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 寄生物

研究领域 >> 感染

[参考文献]

[1]. Theodorides VJ, et al. Anthelmintic activity of albendazole against liver flukes, tapeworms., lung and gastrointestinal roundworms. Experientia. 1976 Jun 15;32(6):702-3.

[相关活性小分子]

阿苯达唑物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 熔点 ]:
207-211°C（分解）

[ 分子式 ]:
C₁₂H₁₅N₃O₂S

[ 分子量 ]:
265.331

[ 精确质量 ]:
265.088501

[ PSA ]:
92.31000

[ LogP ]:
3.07

[ 外观性状 ]:
白色至淡黄色结晶性粉末，无臭。

[ 折射率 ]:
1.634

[ 储存条件 ]:
0-6°C

[ 水溶解性 ]:
微溶于有机溶剂，不溶于水

阿苯达唑MSDS

阿苯达唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: FD1100000

CHEMICAL NAME :: Carbamic acid, (5-(propylthio)-1H-benzimidazol-2-yl)-, methyl ester

CAS REGISTRY NUMBER :: 54965-21-8

LAST UPDATED :: 199806

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C12-H15-N3-O2-S

MOLECULAR WEIGHT :: 265.36

WISWESSER LINE NOTATION :: T56 BM DNJ CMVO1 GS3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 265 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - hamster

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 71 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 85 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 30 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 60 mg/kg

SEX/DURATION :: female 10-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 20 mg/kg

SEX/DURATION :: female 17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Yeast - Saccharomyces cerevisiae

DOSE/DURATION :: 20 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 343,185,1995

阿苯达唑安全信息

[ 符号 ]:

GHS08

[ 信号词 ]:
Warning

[ 危害声明 ]:
H361-H373

[ 警示性声明 ]:
P281

[ 靶器官 ]:
Blood

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
T

[ 风险声明 (欧洲) ]:
R61:May cause harm to the unborn child. R36/37/38:Irritating to eyes, respiratory system and skin .

[ 安全声明 (欧洲) ]:
S53-S45-S37/39-S26

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
FD1100000

[ 海关编码 ]:
3004909090

阿苯达唑合成路线

阿苯达唑上下游产品

阿苯达唑上游产品

阿苯达唑下游产品

阿苯达唑制备

方法1：硫化钠溶于95%乙醇中，在50℃下加入2-硝基-4-硫氰酸酯基苯胺。在60℃下搅拌，冷却到40℃，一次性加入溴丙烷。于40℃反应后再升至60℃反应。加入硫化钠，在80℃下反应。减压蒸出乙醇，加入水。冷却，用氯仿提取。提取液水洗，干燥，加入S-甲基-N，N-二(甲氧羰基)异硫脲和冰醋酸，回流。蒸出氯仿，加入甲醇。冷却，抽滤，用甲醇洗涤，干燥，得阿苯达唑粗品。

方法2：在搅拌和冰浴冷却下，往氯磺酸中缓慢加入多菌灵，保持内温15～20℃。加毕在40℃下搅拌。在0℃以下，把反应液缓慢滴到95%乙醇中。滤集沉淀，以少量乙醇洗，干燥，得氯磺化产物，收率90。8%。把该氯磺化产物加到甲酸、水和40%氢溴酸的溶液中，再加金属铝粉。在35～40℃下搅拌，再在60～65℃下反应。冷却后过滤，滤液用40%氢氧化钠调至Ph值3。滤集沉淀，洗涤，干燥，得巯基化物，收率82.5%。将该巯基化物加到氢氧化钠水溶液中，活性炭脱色。加入溴化四丁基铵，再加入溴丙烷的甲醇溶液，在35～40℃下反应。冷却，滤集沉淀，洗至中性，干燥，得白色结晶的阿苯达唑，收率87.5%，熔点207～209℃。

多菌灵在冰乙酸存在下，和硫氰酸钠反应，引入硫氰基后，再用硫化钠还原后和溴丙烷反应，也得阿苯达唑。
阿苯达唑可用下列方法精制：粗阿苯达唑(以干品计)和85%工业甲酸(1：3.5)一起搅拌升至60℃，待粗品完全溶解后，依次加入连二硫酸钠、活性炭和EDTA。继续搅拌升温至80℃保温。抽滤，滤液倾入去离子水中，在搅拌下用18%～20%氨水中和至Ph值6.5。抽滤，干燥，得白色产品，熔点206～212℃，精制收率93%～94%。

阿苯达唑海关

[ 海关编码 ]: 2933990013

[ 中文概述 ]:
2933990013 多菌灵,苯菌灵,氰菌灵,麦穗宁,氟哒嗪草酯等〔包括咪菌威,丙硫多菌灵,氟氯菌核利,哒菌酮,拌种咯,杀草强〕。监管条件:S(进出口农药登记证明)。增值税率:17.0%。退税率:9.0%。最低关税:6.5%。普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ 监管条件 ]: S.进出口农药登记证明

[ Summary ]:
2933990013 6-(3,5-dichloro-4-methylphenyl)pyridazin-3(2h)-one。supervision conditions:s(import or export registration certificate for pesticides)。VAT:17.0%。tax rebate rate:9.0%。MFN tarrif:6.5%。general tariff:20.0%

阿苯达唑文献

Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing.

Nat. Commun. 6 , 6410, (2015)

In this study, we show that several microtubule-destabilizing agents used for decades for treatment of cancer and other diseases also sensitize cancer cells to oncolytic rhabdoviruses and improve ther...

Phenotypic and genotypic characterisation of Haemonchus spp. and other gastrointestinal nematodes resistant to benzimidazole in infected calves from the tropical regions of Campeche State, Mexico.

Vet. Parasitol. 205(1-2) , 246-54, (2014)

The aim of this study was to identify the presence of anthelmintic resistance to benzimidazole (BZ) in gastrointestinal nematodes (GIN) from naturally infected calves in the tropical regions of Campec...

Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.

Chem. Res. Toxicol. 23 , 171-83, (2010)

Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental...

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