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盐酸六氢芬宁

盐酸六氢芬宁用途

Drofenine盐酸盐是一种有效的竞争性胆碱酯酶抑制剂, ki值为3 uM。

盐酸六氢芬宁名称

[ CAS 号 ]:
548-66-3

[ 中文名 ]:
盐酸六氢芬宁

[ 英文名 ]:
Drofenine hydrochloride

[英文别名 ]:

cyclovegantine
hexahydroadiphenine
cycloadiphenine
Cyclovegantin*Hydrochlorid
Cycloadiphenin*Hydrochlorid
Drofeninhydrochlorid
it-19
DROFENINE HCL
trasentinh
DrofeninHCl

盐酸六氢芬宁生物活性

[ 描述 ]:

Drofenine盐酸盐是一种有效的竞争性胆碱酯酶抑制剂, ki值为3 uM。

[ 相关类别 ]:

信号通路 >> 神经信号通路 >> 疼痛

研究领域 >> 神经疾病

[参考文献]

[1]. Bodur E, et al. Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase. Arch Biochem Biophys. 2001 Feb 1;386(1):25-29.

[相关活性小分子]

盐酸六氢芬宁物理化学性质

[ 沸点 ]:
417.4ºC at 760mmHg

[ 熔点 ]:
145-147°

[ 分子式 ]:
C₂₀H₃₂ClNO₂

[ 分子量 ]:
353.92700

[ 闪点 ]:
124.6ºC

[ 精确质量 ]:
353.21200

[ PSA ]:
29.54000

[ LogP ]:
5.03750

[ 外观性状 ]:
粉末

[ 储存条件 ]:
2-8°C

盐酸六氢芬宁MSDS

详细MSDS(安全技术说明书)

盐酸六氢芬宁毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GU6825000

CHEMICAL NAME :: Cyclohexaneacetic acid, alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride

CAS REGISTRY NUMBER :: 548-66-3

LAST UPDATED :: 199706

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C20-H31-N-O2.Cl-H

MOLECULAR WEIGHT :: 353.98

WISWESSER LINE NOTATION :: L6TJ AYR&VO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 3,238,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1201 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 3,238,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CKFRAY Ceskoslovenska Farmacie. (PNS-Ustredni Expedice a Dovoz Tisku, Kafkova 19, 160 00 Prague 6, Czechoslovakia) V.1- 1952- Volume(issue)/page/year: 3,238,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 28,37,1965

盐酸六氢芬宁安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
GU6825000

盐酸六氢芬宁文献

Simultaneous determination of hydrochloride salts of adiphenine, diphenhydramine, ethyldiphenacetate, drofenine and promazine by ion-pair HPLC.

Boll. Chim. Farm. 122(8) , 405-11, (1983)

Functional and direct binding studies using subtype selective muscarinic receptor antagonists.

Br. J. Pharmacol. 93(3) , 491-500, (1988)

1. Muscarinic receptor antagonists were examined in direct binding studies on guinea-pig cardiac and cortical muscarinic receptors. Pirenzepine, dicyclomine and hexahydroadiphenine were shown to be se...

Inhibition effects of benactyzine and drofenine on human serum butyrylcholinesterase.

Arch. Biochem. Biophys. 386(1) , 25-9, (2001)

Benactyzine and drofenine are widely used anticholinergic drugs. Benactyzine is used to treat organophosphate poisoning and drofenine acts on smooth muscle to stop muscle spasms. Both of these drugs a...

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