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磺胺嘧啶钠

磺胺嘧啶钠用途

Sulfadiazine sodium 属于磺胺类抗生素,兽医用途,主要用于猪产业。Sulfadiazine sodium 也对弓形虫病有效。

磺胺嘧啶钠名称

[ CAS 号 ]:
547-32-0

[ 中文名 ]:
磺胺嘧啶钠盐(SD-Na)

[ 英文名 ]:
Sulfadiazine sodium

[中文别名 ]:

[英文别名 ]:

sulfadiazine sodium
MFCD00067333
Sodium sulfadiazine
Sulphadiazine sodium
EINECS 208-919-0

磺胺嘧啶钠生物活性

[ 描述 ]:

Sulfadiazine sodium 属于磺胺类抗生素,兽医用途,主要用于猪产业。Sulfadiazine sodium 也对弓形虫病有效。

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[体内研究]

本研究评价磺胺嘧啶钠和乙胺嘧啶治疗不同非典型弓形虫株急性感染小鼠的疗效。瑞士小鼠感染了7株弓形虫。用磺胺嘧啶钠10-640毫克/千克/天、乙胺嘧啶3-200毫克/千克/天或两种低剂量药物联合治疗感染小鼠。采用描述性分析评估钠和/或乙胺嘧啶敏感性与基因型之间的关系。TgCTBr4和TgCTBr17菌株(108基因型)对钠或乙胺的敏感性较低。TgCTBr1和TgCTBr25菌株(基因型206)对吡咯的敏感性相似,但对钠的敏感性不明显。TgCTBr9菌株(基因型11)是唯一对两种药物治疗都有高易感性的菌株[1]。

[参考文献]

[1]. Kopmann C, et al. Abundance and transferability of antibiotic resistance as related to the fate of sulfadiazine in maize rhizosphere and bulk soil. FEMS Microbiol Ecol. 2013 Jan;83(1):125-34.

[2]. Silva LA, et al. Efficacy of sulfadiazine and pyrimetamine for treatment of experimental toxoplasmosis with strains obtained from human cases of congenital disease in Brazil. Exp Parasitol. 2019 Jul;202:7-14.

磺胺嘧啶钠物理化学性质

[ 密度 ]:
1.496g/cm3

[ 沸点 ]:
512.6ºC at 760 mmHg

[ 分子式 ]:
C₁₀H₉N₄NaO₂S

[ 分子量 ]:
272.259

[ 闪点 ]:
263.8ºC

[ 精确质量 ]:
272.034393

[ PSA ]:
97.56000

[ LogP ]:
2.38040

[ 外观性状 ]:
白色至灰白色结晶粉末

[ 储存条件 ]:
2-8°C

磺胺嘧啶钠MSDS

详细MSDS(安全技术说明书)

磺胺嘧啶钠毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WP2000000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-2-pyrimidinyl-, monosodium salt

CAS REGISTRY NUMBER :: 547-32-0

LAST UPDATED :: 199304

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C10-H9-N4-O2-S.Na

MOLECULAR WEIGHT :: 272.28

WISWESSER LINE NOTATION :: T6N CNJ BMSWR DZ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1747 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,17,1944

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1408 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AMSSAQ Acta Medica Scandinavica, Supplement. (Almqvist & Wiksell, POB 45150, S-10430 Stockholm, Sweden) No.1-730, 1921-88. Volume(issue)/page/year: 142,64,1943

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 1440 mg/kg

SEX/DURATION :: female 1 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 101,362,1951

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Multiple routes

DOSE :: 2400 mg/kg

SEX/DURATION :: female 6-7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 101,362,1951

磺胺嘧啶钠安全信息

[ 符号 ]:

GHS07, GHS08

[ 信号词 ]:
Danger

[ 危害声明 ]:
H302-H315-H317-H319-H334-H335

[ 警示性声明 ]:
P261-P280-P305 + P351 + P338-P342 + P311

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
22-36/37/38-42/43

[ 安全声明 (欧洲) ]:
22-26-36/37-45

[ 危险品运输编码 ]:
3249

[ WGK德国 ]:
3

[ RTECS号 ]:
WP2000000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1(b)

[ 海关编码 ]:
2935009090

磺胺嘧啶钠海关

[ 海关编码 ]: 2933599090

[ 中文概述 ]:
2933599090. 其他结构上有嘧啶环的化合物(包括其他结构上有哌嗪环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%