替贝碘胺

替贝碘胺用途

碘化替苯唑铵是一种口咽消毒剂,具有预防口腔感染的抗菌活性[1]。

替贝碘胺名称

[ CAS 号 ]:
54663-47-7

[ 中文名 ]:
替贝碘胺

[ 英文名 ]:
Tibezonium iodide

[中文别名 ]:

[英文别名 ]:

替贝碘胺生物活性

[ 描述 ]:

碘化替苯唑铵是一种口咽消毒剂,具有预防口腔感染的抗菌活性[1]。

[ 相关类别 ]:

研究领域 >> 感染
信号通路 >> 抗感染 >> 细菌

[体外研究]

碘化泰菌(5-10μg/mL；15-30分钟)对革兰氏阳性菌显示出良好的抑菌和杀菌活性,尤其是对金黄色葡萄球菌和人化脓性葡萄球菌具有最小抑制浓度(MIC)值≤1微克/毫升[3]。碘化泰(0.25-5μg/mL；30分钟)对金黄色葡萄球菌和化脓性葡萄球菌821的杀菌活性增强,而pH值从6.5-7.0上升到8.0-8.5[3]。

[参考文献]

[1]. M Veronese, et al. Mutagenicity studies on tibezonium, a new oropharyngeal disinfectant. Arzneimittelforschung. 1983;33(3):369-72.

[2]. M Calzavara, et al. [Clinico-experimental study of a new antibactorial agent for local use in stomatology]. Minerva Stomatol. Apr-Jun 1976;25(2):55-66.

[3]. Veronese M, et al. Antimicrobial activity of tibezonium (TBZ). Chemotherapy. 1977. 23(2):90-7.

替贝碘胺物理化学性质

[ 熔点 ]:
162ºC

[ 分子式 ]:
C28H32IN3S2

[ 分子量 ]:
601.60800

[ 精确质量 ]:
601.10800

[ PSA ]:
75.32000

[ LogP ]:
3.48710

替贝碘胺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KH2770000
CHEMICAL NAME :
Ethanaminium, N,N-diethyl-N-methyl-2-((4-(4-(phenylthio)phenyl)- 3H-1,5-benzodiazepin-2-yl) thio)-, iodide
CAS REGISTRY NUMBER :
54663-47-7
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C28-H32-N3-S2.I
MOLECULAR WEIGHT :
601.65
WISWESSER LINE NOTATION :
T67 GN KN IHJ HS2K2&2&2 JR DSR &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,152,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975

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