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6-氯嘌呤核苷

6-氯嘌呤核苷用途

氯嘌呤核苷是嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制DNA合成、诱导细胞凋亡等[1]。

6-氯嘌呤核苷名称

[ CAS 号 ]:
5399-87-1

[ 中文名 ]:
6-氯嘌呤核苷

[ 英文名 ]:
6-Chloropurineriboside

[中文别名 ]:

[英文别名 ]:

6-Chloronebularine
6-CHLOROINOSINE
9H-Purine, 6-chloro-9-β-D-ribofuranosyl-
6-Chloropurine riboside
6-Chloropurine ribos
6-Choropurine Riboside
6-Chloropurineriboside
6-Chloropurine-9-Beta-D-ribofuranoside
EINECS 217-904-8
2',3',5'-tri-O-acetyl-6-chloro adenosine

6-氯嘌呤核苷生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 癌症

信号通路 >> 细胞周期/DNA损伤 >> 核苷抗代谢药/类似物

[参考文献]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

6-氯嘌呤核苷物理化学性质

[ 密度 ]:
2.0±0.1 g/cm3

[ 沸点 ]:
614.8±65.0 °C at 760 mmHg

[ 熔点 ]:
161-163ºC (dec.)

[ 分子式 ]:
C₁₀H₁₁ClN₄O₄

[ 分子量 ]:
286.67

[ 闪点 ]:
325.6±34.3 °C

[ 精确质量 ]:
286.046875

[ PSA ]:
113.52000

[ LogP ]:
-0.56

[ 外观性状 ]:
无色结晶粉末

[ 蒸汽压 ]:
0.0±1.9 mmHg at 25°C

[ 折射率 ]:
1.846

[ 储存条件 ]:
2-8°C

6-氯嘌呤核苷MSDS

详细MSDS(安全技术说明书)

6-氯嘌呤核苷安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2942000000

6-氯嘌呤核苷海关

[ 海关编码 ]: 2934999090

[ 中文概述 ]:
2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

6-氯嘌呤核苷文献

Evidence on the existence of a purine ligand induced conformational change in the active site of bovine pancreatic ribonuclease A studied by proton nuclear magnetic resonance spectroscopy.

Biochemistry 21(18) , 4290-7, (1982)

The titration curves of the C-2 histidine protons of RNase A and of derivative II--a covalent derivative obtained by reaction of the enzyme with the halogenated nucleotide 9-beta-D-ribofuranosyl-6-chl...

Synthesis, biological evaluation and molecular modeling studies of N6-benzyladenosine analogues as potential anti-toxoplasma agents.

Biochem. Pharmacol. 73 , 1558-1572, (2007)

Toxoplasma gondii is an opportunistic pathogen responsible for toxoplasmosis. T. gondii is a purine auxotroph incapable of de novo purine biosynthesis and depends on salvage pathways for its purine re...

Synthesis and biological evaluation of nucleoside analogues having 6-chloropurine as anti-SARS-CoV agents.

Bioorg. Med. Chem. Lett. 17 , 2470-3, (2007)

Nucleoside analogues that have 6-chloropurine as the nucleobase were synthesized and evaluated for anti-SARS-CoV activity by plaque reduction and yield reduction assays in order to develop novel anti-...

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