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甘草酸铵

甘草酸铵用途

Monoammonium glycyrrhizinate hydrate 具有抗炎、抗过敏、抗胃溃疡、抗肝炎等药理活性。

甘草酸铵名称

[ CAS 号 ]:
53956-04-0

[ 中文名 ]:
甘草酸铵

[ 英文名 ]:
Glycyrrhizic acid ammonium salt

[中文别名 ]:

[英文别名 ]:

GLYCAMIL
Ammoniumglycynhizinato
glycyrrhizic acid monoammonium salt
ammonium glycyrrhizinate
MFCD00167400
Glycyrrhizin Monoammonium Salt Hydrate
Glycyrrhizic Acid Monoammonium Salt Hydrate
GLYCYRRHIZICAMMONIUM
Magnasweet
ammoniate

甘草酸铵生物活性

[ 描述 ]:

Monoammonium glycyrrhizinate hydrate 具有抗炎、抗过敏、抗胃溃疡、抗肝炎等药理活性。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

研究领域 >> 炎症/免疫

[体内研究]

通过高剂量和中剂量的MAG(10和30mg/kg)给药,肺W/D重量比的增加显着降低。用MAG(10和30mg/kg)预处理有效地减少TNF-α和IL-1β的产生。与LPS相比,MAG(10,30mg/kg)显着降低NF-κBp65蛋白表达。相反,与对照组相比,LPS显着降低IκB-α蛋白表达,而与LPS组相比,MAG(10和30mg/kg)显着增加IκB-α表达[1]。与RIF和INH组相比,低剂量和高剂量MAG治疗在14和21天时间点显着降低AST,ALT,TBIL和TBA水平,表明MAG对RIF-和INH-的保护作用。诱发肝损伤。 MAG处理组在7,14和21 d时间点提高肝脏GSH水平,并在RIF和INH处理的大鼠中在14和21 d时间点显着降低MDA水平,表明MAG在RIF-和中的保护作用。 INH诱发肝损伤[2]。

[动物实验]

小鼠[1]在该研究中，使用BALB / c小鼠（雄性，6-8周龄，20-25g）。将小鼠随机分成5组：对照组，LPS组和LPS +甘草酸单铵（MAG：3,10和30mg / kg）组。每组包含8只小鼠。用腹膜内注射戊巴比妥钠（50mg / kg）麻醉小鼠。在诱导急性肺损伤之前，给小鼠腹膜内注射MAG（3,10和30mg / kg）。 1小时后，气管内滴注LPS（5mg / kg）以诱导急性肺损伤。正常小鼠给予PBS [1]。大鼠[2]使用雄性Wistar大鼠（180-220g）。将大鼠随机分为4组，即对照组，RIF和INH组，MAG低剂量组和MAG高剂量组，每组15只。 RIF和INH组大鼠每天一次灌胃给予RIF（60mg / kg）和INH（60mg / kg）; MAG组中的大鼠用MAG以45或90mg / kg的剂量预处理，在MAG给药后3小时给予RIF（60mg / kg）和INH（60mg / kg）;对照组大鼠用生理盐水处理。为了评估药物的动态效应，在给药后7,14和21天处死各组大鼠[2]。

[参考文献]

[1]. Huang X, et al. Anti-Inflammatory Effects of Monoammonium Glycyrrhizinate on Lipopolysaccharide-Induced Acute Lung Injury in Mice through Regulating Nuclear Factor-Kappa B Signaling Pathway. Evid Based Complement Alternat Med. 2015;2015:272474.

[2]. Zhou L, et al. Monoammonium glycyrrhizinate protects rifampicin- and isoniazid-induced hepatotoxicity via regulating the expression of transporter Mrp2, Ntcp, and Oatp1a4 in liver. Pharm Biol. 2016;54(6):931-7.

[相关活性小分子]

甘草酸铵物理化学性质

[ 密度 ]:
1.43g/cm3

[ 沸点 ]:
971.4ºC at 760mmHg

[ 熔点 ]:
209ºC

[ 分子式 ]:
C₄₂H₆₅NO₁₆

[ 分子量 ]:
839.96

[ 闪点 ]:
288.1ºC

[ PSA ]:
272.70000

[ LogP ]:
0.32860

[ 外观性状 ]:
白色结晶粉末

[ 折射率 ]:
49 ° (C=1.5, EtOH)

[ 储存条件 ]:
2-8°C

[ 水溶解性 ]:
Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides.

甘草酸铵MSDS

详细MSDS(安全技术说明书)

甘草酸铵毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LZ6500000

CHEMICAL NAME :: alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en- 3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate

CAS REGISTRY NUMBER :: 53956-04-0

LAST UPDATED :: 199712

DATA ITEMS CITED :: 14

MOLECULAR FORMULA :: C42-H62-O16.H3-N

MOLECULAR WEIGHT :: 840.08

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9818 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 540 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 224 mg/kg/26W-C

TOXIC EFFECTS :: Cardiac - changes in heart weight Kidney, Ureter, Bladder - changes in bladder weight Endocrine - changes in adrenal weight

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 840 mg/kg/30D-I

TOXIC EFFECTS :: Liver - hepatitis (hepatocellular necrosis), diffuse Blood - changes in leukocyte (WBC) count Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - phosphatases

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 350 gm/kg

SEX/DURATION :: male 10 week(s) pre-mating

TOXIC EFFECTS :: Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 235 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 7479 mg/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - urogenital system Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 350 gm/kg/10W (Continuous)

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB279-650 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5765 No. of Facilities: 3 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 221 (estimated) No. of Female Employees: 144 (estimated)

甘草酸铵安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xn

[ 危险品运输编码 ]:
UN 3077 9 / PGIII

[ WGK德国 ]:
2

[ RTECS号 ]:
LZ6500000

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甘草酸铵文献

The HMGB1 protein sensitizes colon carcinoma cells to cell death triggered by pro-apoptotic agents.

Int. J. Oncol. 46(2) , 667-76, (2014)

The HMGB1 protein has multiple functions in tumor biology and can act both as a transcription factor and as a cytokine. HMGB1 is released during cell death, and in our previous studies we demonstrated...

TLR9 activation is triggered by the excess of stimulatory versus inhibitory motifs present in Trypanosomatidae DNA.

PLoS Negl. Trop. Dis. 8(11) , e3308, (2014)

DNA sequences purified from distinct organisms, e.g. non vertebrate versus vertebrate ones, were shown to differ in their TLR9 signalling properties especially when either mouse bone marrow-derived- o...

Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1.

Int. Immunopharmacol. 26 , 112-8, (2015)

High mobility group box 1 (HMGB1) is now recognized as a late mediator of sepsis. Although glycyrrhizin was known as inhibitor of HMGB1, it is not yet clear underlying mechanism(s). We found that glyc...

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