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acridine-3,6-diamine dihydrochloride

acridine-3,6-diamine dihydrochloride用途

盐酸普罗夫拉嗪(3,6-二氨基吖啶)是一种吖啶染料,是一种DNA嵌入剂和抗菌剂。盐酸普罗夫拉胺作为Kir3.2的孔隙阻滞剂。盐酸普罗夫林是治疗Kir3.2相关神经系统疾病的潜在先导化合物[1][2][3]。

acridine-3,6-diamine dihydrochloride名称

[ CAS 号 ]:
531-73-7

[ 英文名 ]:
acridine-3,6-diamine dihydrochloride

[英文别名 ]:

Proflavine dihydrochloride
2,8-Diaminoacridinium chloride hydrochloride
EINECS 208-515-4
Acridine-3,6-diamine dihydrochloride
ACRIDINE,3,6-DIAMINO-,DIHYDROCHLORIDE
3,6-Diaminoacridinium chloride hydrochloride
proflavin.2HCl
3,6-Diaminoacridine dihydrochloride
acridine-3,6-diamine,dihydrochloride

acridine-3,6-diamine dihydrochloride生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 感染

信号通路 >> 抗感染 >> 细菌

[参考文献]

[1]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

[2]. Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.

[3]. Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.

acridine-3,6-diamine dihydrochloride物理化学性质

[ 沸点 ]:
506.9ºC at 760mmHg

[ 分子式 ]:
C₁₃H₁₃Cl₂N₃

[ 分子量 ]:
282.17

[ 闪点 ]:
292.9ºC

[ 精确质量 ]:
281.04900

[ PSA ]:
64.93000

[ LogP ]:
5.31880

acridine-3,6-diamine dihydrochloride毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR8700000

CHEMICAL NAME :: Acridine, 3,6-diamino-, dihydrochloride

CAS REGISTRY NUMBER :: 531-73-7

LAST UPDATED :: 199409

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C13-H11-N3.2Cl-H

MOLECULAR WEIGHT :: 282.19

WISWESSER LINE NOTATION :: T C666 BNJ EZ MZ &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Rodent - mouse Ascites tumor

DOSE/DURATION :: 20 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

acridine-3,6-diamine dihydrochloride安全信息

[ 海关编码 ]:
2933990090

acridine-3,6-diamine dihydrochloride海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%