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天青 A

天青 A用途

Azure A(氯化物)是一种吩噻嗪染料。Azure A(氯)是由亚甲基蓝氧化形成的,具有强烈的异色性。Azure A(氯)可用于电化学生物传感的污渍和氧化还原介质的研究[1][2]。

天青 A名称

[ CAS 号 ]:
531-53-3

[ 中文名 ]:
天青A

[ 英文名 ]:
Azure A chloride

[中文别名 ]:

[英文别名 ]:

EINECS 208-510-7
Methyleneazure
N,N,N'-Trimethylthionin
AZURE A, CERTIFIED, PURE
Azure AC.I. 52005
MFCD00012112
Azure A chloride

天青 A生物活性

[ 描述 ]:

[ 相关类别 ]:

研究领域 >> 其他

信号通路 >> 其他 >> 其他

[参考文献]

[1]. Snehalatha M, et al. Azure A chloride: computational and spectroscopic study[J]. Journal of Raman Spectroscopy: An International Journal for Original Work in all Aspects of Raman Spectroscopy, Including Higher Order Processes, and also Brillouin and Rayleigh Scattering, 2009, 40(2): 176-182.

[2]. Shahab S, et al. Photochromic properties of the molecule Azure A chloride in polyvinyl alcohol matrix[J]. Journal of Molecular Structure, 2015, 1101: 109-115.

天青 A物理化学性质

[ 沸点 ]:
442.8ºC at 760 mmHg

[ 熔点 ]:
290 °C (dec.)(lit.)

[ 分子式 ]:
C₁₄H₁₄ClN₃S

[ 分子量 ]:
291.80

[ 闪点 ]:
221.6ºC

[ 精确质量 ]:
291.059692

[ PSA ]:
70.16000

[ 外观性状 ]:
绿色至暗棕色粉末

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents.

天青 AMSDS

天青 A毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SP5660000

CHEMICAL NAME :: Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride

CAS REGISTRY NUMBER :: 531-53-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C14-H14-N3-S.Cl

MOLECULAR WEIGHT :: 291.82

WISWESSER LINE NOTATION :: T C666 BN ISJ FZ MN1&1 &G &12/25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 37720 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 59040 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 19340 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Ovary

DOSE/DURATION :: 20 umol/L/5H (Continuous)

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3031 No. of Facilities: 451 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 2020 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3031 No. of Facilities: 661 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 5132 (estimated) No. of Female Employees: 2765 (estimated)

天青 A安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危害码 (欧洲) ]:
Xi

[ 安全声明 (欧洲) ]:
S22-S24/25

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
SP5660000

[ 海关编码 ]:
2934300000

天青 A合成路线

天青 A上下游产品

天青 A上游产品

天青 A下游产品

天青 A海关

[ 海关编码 ]: 2934300000

[ 中文概述 ]:
2934300000. 含一个吩噻嗪环系的化合物(吩噻嗪环系不论是否氢化,化合物未经进一步稠合的 ). 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

天青 A文献

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.

Hum. Mol. Genet. 23(11) , 2953-67, (2014)

Mutations of Filamin genes, which encode actin-binding proteins, cause a wide range of congenital developmental malformations in humans, mainly skeletal abnormalities. However, the molecular mechanism...

Ligand polarizability contributes to tau fibril binding affinity.

Bioorg. Med. Chem. 19 , 5147-54, (2011)

Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggrega...

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