3,5-二甲氧基-4-羟基肉桂酸，芥子酸

3,5-二甲氧基-4-羟基肉桂酸，芥子酸用途

Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物,为 HDAC 的抑制剂,IC50 值 2.27 mM[1],对 ACE-I 的活性也有抑制作用[2]。Sinapinic acid 具有有效的抗肿瘤活性,诱导肿瘤细胞凋亡[1]。Sinapinic acid 具有抗氧化、抗糖尿病的作用[2]。Sinapinic acid 可以降低卵巢切除大鼠的总胆固醇、甘油三酯和 HOMA-IR 指数,并使抗氧化能力和氧化损伤的一些血清参数正常化[3]。

3,5-二甲氧基-4-羟基肉桂酸，芥子酸名称

[ CAS 号 ]:
530-59-6

[ 中文名 ]:
芥子酸

[ 英文名 ]:
Sinapic acid

[中文别名 ]:

[英文别名 ]:

4-Hydroxy-3,5-dimethoxycinnamic acid
Sinapic acid
3,5-Dimethoxy-4-hydroxycinnamic Acid
Sinapic acid, trans-
3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid
3 5-dimethoxy-4-hydroxycinnamic acid
(2E)-3-(4-Hydroxy-3,5-dimethoxyphenyl)acrylic acid
Sinapinic acid
3,5-DIMETHOXY-4-HYDROXY-TRANS-CINNAMIC ACID
(E)-sinapic acid

3,5-二甲氧基-4-羟基肉桂酸，芥子酸生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 代谢酶/蛋白酶 >> 血管紧张素转换酶(ACE)

研究领域 >> 癌症

研究领域 >> 代谢疾病

天然产物 >> 酚类

[ 靶点 ]

HDAC:2.27 mM (IC50)

ACE-I

[体外研究]

芥子酸作为HDAC的抑制剂,IC50为2.27 mM [1]。芥子酸还抑制ACE-1活性[2]。芥子酸抑制HeLa细胞中的HDAC活性,抑制HeLa和HT29细胞的生长,在72小时时IC50分别为0.91±0.02mM和1.6±0.02mM,诱导这些癌细胞的凋亡[1]。

[体内研究]

芥子酸(5或25 mg/kg,每日口服4周)可提高血清雌二醇浓度;降低胰岛素抵抗和甘油三酯和总胆固醇浓度;并且有利地影响大鼠抗氧化能力(减少谷胱甘肽,超氧化物歧化酶)和氧化损伤的参数[3]。

[参考文献]

[1]. Senawong T, et al. Histone deacetylase (HDAC) inhibitory and antiproliferative activities of phenolic-rich extracts derived from the rhizome of Hydnophytum formicarum Jack.: sinapinic acid acts as HDAC inhibitor. BMC Complement Altern Med. 2013 Sep 22;13:232.

[2]. Quinn L, et al. Extraction and Quantification of Sinapinic Acid from Irish Rapeseed Meal and Assessment of Angiotensin-I Converting Enzyme (ACE-I) Inhibitory Activity. J Agric Food Chem. 2017 Aug 16;65(32):6886-6892.

[3]. Zych M, et al. The Effects of Sinapic Acid on the Development of Metabolic Disorders Induced by Estrogen Deficiency in Rats. Oxid Med Cell Longev. 2018 Jun 4;2018:9274246.

[相关活性小分子]

3,5-二甲氧基-4-羟基肉桂酸，芥子酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
403.4±40.0 °C at 760 mmHg

[ 熔点 ]:
203-205 °C (dec.)(lit.)

[ 分子式 ]:
C₁₁H₁₂O₅

[ 分子量 ]:
224.210

[ 闪点 ]:
158.6±20.8 °C

[ 精确质量 ]:
224.068466

[ PSA ]:
75.99000

[ LogP ]:
1.29

[ 外观性状 ]:
黄色-棕色结晶粉末

[ 蒸汽压 ]:
0.0±1.0 mmHg at 25°C

[ 折射率 ]:
1.604

[ 储存条件 ]:
室温

[ 稳定性 ]:
Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.

[ 水溶解性 ]:
insoluble

3,5-二甲氧基-4-羟基肉桂酸，芥子酸MSDS

详细MSDS(安全技术说明书)

3,5-二甲氧基-4-羟基肉桂酸，芥子酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant;

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ 海关编码 ]:
2918990090

3,5-二甲氧基-4-羟基肉桂酸，芥子酸合成路线

详细合成路线

3,5-二甲氧基-4-羟基肉桂酸，芥子酸海关

[ 海关编码 ]: 2918990090

[ 中文概述 ]:
2918990090. 其他含其他附加含氧基羧酸（包括酸酐、酰卤化物、过氧化物和过氧酸及该税号的衍生物）. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

3,5-二甲氧基-4-羟基肉桂酸，芥子酸文献

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We cloned, overexpressed and purified Vibrio cholerae FtsZ protein for the first time. We used several complementary techniques to probe and compare the comparative assembly properties of recombinant ...

Antimicrobial activity of natural products from the flora of Northern Ontario, Canada.

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The number of multidrug resistant (MDR) microorganisms is increasing and the antimicrobial resistance expressed by these pathogens is generating a rising global health crisis. In fact, there are only ...

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