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2-硝基咪唑

2-硝基咪唑用途

Azomycin 是一种抗生素,可以抑制有氧革兰氏阳性菌和革兰氏阴性菌的生长。

2-硝基咪唑名称

[ CAS 号 ]:
527-73-1

[ 中文名 ]:
2-硝基咪唑

[ 英文名 ]:
2-Nitroimidazole

[中文别名 ]:

[英文别名 ]:

2-Nitroimidazol
Azomycin
2-Nitro-1H-imidazole
MFCD00005185
2-Nitroimidazole
EINECS 208-425-5
1H-Imidazole, 2-nitro-

2-硝基咪唑生物活性

[ 描述 ]:

Azomycin 是一种抗生素,可以抑制有氧革兰氏阳性菌和革兰氏阴性菌的生长。

[ 相关类别 ]:

信号通路 >> 抗感染 >> 细菌

研究领域 >> 感染

[ 靶点 ]

Bacterial[1]

[体外研究]

Azomycin是一种抗生素,可以对抗好氧革兰氏阳性和革兰氏阴性细菌。研究发现,Azomycin对多种厌氧菌也具有活性[1]。

[参考文献]

[1]. Shoji JH, et al. Isolation of azomycin from Pseudomonas fluorescens. J Antibiot (Tokyo). 1989 Oct;42(10):1513-4.

[相关活性小分子]

2-硝基咪唑物理化学性质

[ 密度 ]:
1.6±0.1 g/cm3

[ 沸点 ]:
373.6±25.0 °C at 760 mmHg

[ 熔点 ]:
287 °C (dec.)(lit.)

[ 分子式 ]:
C₃H₃N₃O₂

[ 分子量 ]:
113.075

[ 闪点 ]:
179.7±23.2 °C

[ 精确质量 ]:
113.022530

[ PSA ]:
74.50000

[ LogP ]:
0.15

[ 外观性状 ]:
黄色橙色粉末

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.612

[ 储存条件 ]:
Refrigerator

[ 水溶解性 ]:
insoluble

2-硝基咪唑MSDS

2-硝基咪唑毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI7875000

CHEMICAL NAME :: Imidazole, 2-nitro-

CAS REGISTRY NUMBER :: 527-73-1

BEILSTEIN REFERENCE NO. :: 0116444

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C3-H3-N3-O2

MOLECULAR WEIGHT :: 113.09

WISWESSER LINE NOTATION :: T5M CNJ BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Microorganism - not otherwise specified

DOSE/DURATION :: 1 mg/plate

REFERENCE :: JGAMA9 Journal of General and Applied Microbiology. (Microbiology Research Foundation, c/o Japan Academic Soc. Center Bldg., 2-4-16 Yayoi, Bunkyo-ku, Tokyo, 113, Japan) V.1- 1955- Volume(issue)/page/year: 11,129,1965 *** REVIEWS *** TOXICOLOGY REVIEW ADCMAZ Advances in Chemotherapy. (New York, NY) V.1-3, 1964-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 3,39,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6614 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

2-硝基咪唑安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36

[ 危险品运输编码 ]:
UN 2811 6.1/PG 3

[ WGK德国 ]:
3

[ RTECS号 ]:
NI7875000

[ 包装等级 ]:
III

[ 危险类别 ]:
6.1

[ 海关编码 ]:
2933990090

2-硝基咪唑合成路线

2-硝基咪唑上下游产品

2-硝基咪唑上游产品

2-硝基咪唑下游产品

2-硝基咪唑制备

将氨基乙缩醛S-甲基异硫及水混匀，搅拌加热，减压蒸干，残留物加甲醇溶解，然后滴加丙酮，得白色结晶N-（2，2-二乙氧基乙基）胍硫酸盐，收率84.4%。取N-（2，2-二乙氧基乙基）胍硫酸盐和浓盐酸混合，搅拌加热回流，反应毕，加蒸馏水减压蒸干，再加水蒸干，残留物用无水乙醇溶解，然后滴加无水乙醚，得白色固体2-氨基咪唑，收率64.5%。2-氨基咪唑，加入氟硼酸及水，冷至 -15 ℃ 以下，搅拌下滴加硝酸钠和水配成的溶液。加毕，继续搅拌。将反应生成的棕绿色溶液倒入五水合硫酸铜溶液中，边加边搅，再加入亚硝酸钠继续搅拌，反应毕，加浓盐酸调pH至2，用乙酸酯提取，提取液经无水硫酸钠干燥后回收乙酸乙酯至尽，残留物用乙醇重结晶，得2-硝基咪唑。

2-硝基咪唑海关

[ 海关编码 ]: 2933290090

[ 中文概述 ]:
2933290090. 其他结构含非稠合咪唑环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-硝基咪唑文献

A (99m)Tc-labeled misonidazole analogue: step toward a (99m)Tc-alternative to [18F]fluromisonidazole for detecting tumor hypoxia.

Cancer Biother. Radiopharm. 30(2) , 79-86, (2015)

The PET radiopharmaceutical [(18)F]Fluromisonidazole ([(18)F]FMISO) is presently the agent of choice for the clinical imaging of tumor hypoxia. Considering the logistic advantages of (99m)Tc and wider...

The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia.

J. Nucl. Med. 43(6) , 837-50, (2002)

The cyclam ligand (1,4,8,11-tetraazacyclotetradecane) was condensed with various azomycin-containing synthons to produce chemical compounds that could chelate radioactive metals. It was expected that ...

The oxygen dependence of the reduction of nitroimidazoles in a radiolytic model system.

Int. J. Radiat. Oncol. Biol. Phys. 10(8) , 1323-6, (1984)

Radiation chemical reductions using eaq- and CO2- have been carried out in the presence of oxygen with metronidazole, p-nitroacetophenone, misonidazole and three other 2-nitroimidazoles. Low concentra...

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