<生产厂家价格>

二氢红藻氨酸

二氢红藻氨酸用途

二氢红藻氨酸(DHK)是一种谷氨酸转运体GLT1(EAAT2)抑制剂。二氢红藻氨酸损害小鼠的新物体识别(NOR)记忆能力。二氢红藻氨酸也有致痫作用[1]。

二氢红藻氨酸名称

[ CAS 号 ]:
52497-36-6

[ 中文名 ]:
2-羧基-4-异丙基-3-吡咯烷乙酸

[ 英文名 ]:
Dihydrokainic acid

[中文别名 ]:

二氢红藻氨酸

[英文别名 ]:

2-Carboxy-4-isopropyl-3-pyrrolidineacetic acid
MFCD03412037
Dihydrokainic acid

二氢红藻氨酸生物活性

[ 描述 ]:

二氢红藻氨酸(DHK)是一种谷氨酸转运体GLT1(EAAT2)抑制剂。二氢红藻氨酸损害小鼠的新物体识别(NOR)记忆能力。二氢红藻氨酸也有致痫作用[1]。

[ 相关类别 ]:

信号通路 >> 跨膜转运 >> EAAT2

研究领域 >> 神经疾病

[ 靶点 ]

GLT1[1]

[参考文献]

[1]. Tian SW, et al. Glutamate transporter GLT1 inhibitor dihydrokainic acid impairs novel object recognition memory performance in mice. Physiol Behav. 2019 Feb 1;199:28-32.

[2]. Butcher SP, et al. On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat. Neuropharmacology. 1988 Apr;27(4):375-81.

二氢红藻氨酸物理化学性质

[ 密度 ]:
1.187g/cm3

[ 沸点 ]:
416.6ºC at 760mmHg

[ 熔点 ]:
285 °C (dec.)

[ 分子式 ]:
C₁₀H₁₇NO₄

[ 分子量 ]:
215.25

[ 精确质量 ]:
215.11600

[ PSA ]:
86.63000

[ LogP ]:
0.73470

[ 外观性状 ]:
固体

[ 折射率 ]:
1.492

[ 储存条件 ]:
2-8°C

二氢红藻氨酸MSDS

二氢红藻氨酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H312-H332

[ 警示性声明 ]:
P280

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn

[ 风险声明 (欧洲) ]:
20/21/22

[ 安全声明 (欧洲) ]:
26-36

[ 危险品运输编码 ]:
NONH for all modes of transport

[ 海关编码 ]:
2933990090

二氢红藻氨酸合成路线

二氢红藻氨酸上下游产品

二氢红藻氨酸上游产品

二氢红藻氨酸下游产品

二氢红藻氨酸海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

二氢红藻氨酸文献

EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptake.

J. Neurosci. 34(40) , 13472-85, (2014)

The EAAT2 glutamate transporter, accounts for >90% of hippocampal glutamate uptake. Although EAAT2 is predominantly expressed in astrocytes, ∼10% of EAAT2 molecules are found in axon terminals. Despit...

Activation of sodium-dependent glutamate transporters regulates the morphological aspects of oligodendrocyte maturation via signaling through calcium/calmodulin-dependent kinase IIβ's actin-binding/-stabilizing domain.

Glia 62(9) , 1543-58, (2014)

Signaling via the major excitatory amino acid glutamate has been implicated in the regulation of various aspects of the biology of oligodendrocytes, the myelinating cells of the central nervous system...

A functional coupling between extrasynaptic NMDA receptors and A-type K+ channels under astrocyte control regulates hypothalamic neurosecretory neuronal activity.

J. Physiol. 592(Pt 13) , 2813-27, (2014)

Neuronal activity is controlled by a fine-tuned balance between intrinsic properties and extrinsic synaptic inputs. Moreover, neighbouring astrocytes are now recognized to influence a wide spectrum of...

更多文献