乙烯雌酚二磷酸酯
乙烯雌酚二磷酸酯名称
[ CAS 号 ]:
522-40-7
[ 中文名 ]:
乙烯雌酚二磷酸酯
[ 英文名 ]:
fosfestrol
[中文别名 ]:
[英文别名 ]:
- ST52-Asta
- Stilbestrol diphosphate
- Fosfestrolum [INN-Latin]
- Phosphestrol
- Diethylstilbestryl diphosphate
- fosfestrol
- 3,4-Bis-(4-phosphonooxy-phenyl)-hex-3t-en
- Diethylstilbestrol diphosphate
- Phosphoestrolum
- Honvan
乙烯雌酚二磷酸酯物理化学性质
[ 密度 ]:
1.433g/cm3
[ 沸点 ]:
648.7ºC at 760mmHg
[ 分子式 ]:
C18H22O8P2
[ 分子量 ]:
428.31000
[ 闪点 ]:
346.1ºC
[ 精确质量 ]:
428.07900
[ PSA ]:
153.14000
[ LogP ]:
4.36040
[ 折射率 ]:
1.609
乙烯雌酚二磷酸酯毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- WJ5680000
- CHEMICAL NAME :
- 4,4'-Stilbenediol, alpha,alpha'-diethyl-, bis(dihydrogen phosphate), (E)-
- CAS REGISTRY NUMBER :
- 522-40-7
- LAST UPDATED :
- 199504
- DATA ITEMS CITED :
- 12
- MOLECULAR FORMULA :
- C18-H22-O8-P2
- MOLECULAR WEIGHT :
- 428.34
- WISWESSER LINE NOTATION :
- QPQO&OR DY2&UY2&R DOPQQO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 11 mg/kg/3D-I
- TOXIC EFFECTS :
- Vascular - BP lowering not characterized in autonomic section Blood - change in clotting factors Skin and Appendages - sweating
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 425 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 630 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 25 nmol/L
- REFERENCE :
- CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 40,817,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3653 No. of Facilities: 86 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 9667 (estimated) No. of Female Employees: 7994 (estimated)
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