522-40-7

• 常用中文名：乙烯雌酚二磷酸酯
• 常用英文名：fosfestrol
• CAS号：522-40-7
• 分子式：C₁₈H₂₂O₈P₂
• 分子量：428.31000
• 发布时间：2018-08-13 10:52:28
• 更新时间：2026-08-06 16:15:49

名称

• 中文名: 乙烯雌酚二磷酸酯
• 英文名: [4-[(E)-4-(4-phosphonooxyphenyl)hex-3-en-3-yl]phenyl] dihydrogen phosphate
• 中文别名: (E)-4-(4-(4-(膦酰氧基)苯基)己-3-烯-3-基)苯基二氢磷酸酯; (E)-4-(4-(4-(膦酰氧基)苯基)己-3-烯-3-基)苯基磷酸二氢盐; 磷雌酚
• 英文别名: diethylstilbesterol diphosphate; DIETHYLSTILBESTROL DIPHOSPHATE; FOSFESTROL; ST52-Asta; Stilbestrol diphosphate; 3,4-Bis-(4-phosphonooxy-phenyl)-hex-3t-en; DIETHYLSTILBOESTROLDIPHOSPHATE; Diethylstilbestrol diphosphate; Phenol, 4,4'-[(1E)-1,2-diethyl-1,2-ethenediyl]bis-, 1,1'-bis(dihydrogen phosphate); 3-Hexene-3,4-diylbis(4,1-phenylene) bis[dihydrogen (phosphate)]; (e)-4-(4-(4-(Phosphonooxy)phenyl)hex-3-en-3-yl)phenyl dihydrogen phosphate; Phosphestrol; Diethylstilbestryl diphosphate; Honvan; Desdp; Phosphoestrolum; stilboestrol bis(dihydrogen phosphate); (E)-Hex-3-ene-3,4-diylbis(4,1-phenylene) bis(dihydrogen phosphate); alpha,alpha'-diethyl-, bis(dihydrogen phosphate), (e)-4'-stilbenediol; Fosfestrolum [INN-Latin]; alpha,alpha'-diethyl-(e)-4,4'-stilbenediol bis(dihydrogen phosphate); 3,4-bis-(4-phosphonooxy-phenyl)-hex-3t-ene; diethylstilbestrol bisphosphate

物化性质

• 密度: 1.433g/cm3
• 沸点: 648.7ºC at 760mmHg
• 分子式: C₁₈H₂₂O₈P₂
• 分子量: 428.31000
• 闪点: 346.1ºC
• 精确质量: 428.07900
• PSA: 153.14000
• LogP: 4.36040
• 折射率: 1.609

毒性和生态

CHEMICAL IDENTIFICATION RTECS NUMBER : WJ5680000 CHEMICAL NAME : 4,4'-Stilbenediol, alpha,alpha'-diethyl-, bis(dihydrogen phosphate), (E)- CAS REGISTRY NUMBER : 522-40-7 LAST UPDATED : 199504 DATA ITEMS CITED : 12 MOLECULAR FORMULA : C18-H22-O8-P2 MOLECULAR WEIGHT : 428.34 WISWESSER LINE NOTATION : QPQO&OR DY2&UY2&R DOPQQO HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Human - man DOSE/DURATION : 11 mg/kg/3D-I TOXIC EFFECTS : Vascular - BP lowering not characterized in autonomic section Blood - change in clotting factors Skin and Appendages - sweating TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 425 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Oral SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 2 gm/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 630 mg/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value TYPE OF TEST : TDLo - Lowest published toxic dose ROUTE OF EXPOSURE : Intraperitoneal DOSE : 400 mg/kg SEX/DURATION : female 6 day(s) after conception TOXIC EFFECTS : Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material) TYPE OF TEST : Cytogenetic analysis TYPE OF TEST : Sex chromosome loss and nondisjunction MUTATION DATA TYPE OF TEST : Mutation test systems - not otherwise specified TEST SYSTEM : Mammal - species unspecified Lymphocyte DOSE/DURATION : 25 nmol/L REFERENCE : CYTOAN Cytologia. (Japan Pub. Trading Co. (USA), 1255 Howard St., San Francisco, CA 94103) V.1- 1929- Volume(issue)/page/year: 40,817,1975 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3653 No. of Facilities: 86 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 9667 (estimated) No. of Female Employees: 7994 (estimated)

合成路线

56-53-1 ~% 522-40-7

文献：Miles Labor. Inc. Patent: US2971975 , 1955 ; Full Text Show Details Asta-Werke Patent: GB732286 , 1952 ; Full Text Show Details Ciba Pharm. Prod. Inc. Patent: US2234311 , 1939 ; Full Text Show Details Ciba Patent: DE720468 , 1939 ; DRP/DRBP Org.Chem. Full Text Show Details Ciba Patent: CH219518 , 1938 ;

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