鲁米诺

鲁米诺用途

【用途一】
作化学分析试剂、指示剂。
【用途二】
发光测试: Emmax 440 nm (化学发光; 60 mM K2S2O8, 100 mM K2CO3, pH 11.5; 添加H2O2后)化学发光试剂及指示剂，常用于化学发光分析，如金属阳离子、血液免疫等等。

鲁米诺名称

[ CAS 号 ]:
521-31-3

[ 中文名 ]:
发光氨

[ 英文名 ]:
Luminol

[中文别名 ]:

[英文别名 ]:

EINECS 208-309-4
LUMINOL
5-Amino-2,3-dihydrophthalazine-1,4-dione
5-Amino-2,3-dihydro-1,4-phthalazinedione
Dia0003Luminol
o-Aminophthalhydride
LuminolFreeAcid
phthalazinedione
3-aminophthalic hydrazide
Diogenes Reagent

鲁米诺生物活性

[ 描述 ]:

Luminol(Diogenes reagent)是化学发光试剂,与一定的氧化剂反应时能发出蓝光。

[ 相关类别 ]:

信号通路 >> 其他 >> 其他

染料试剂

研究领域 >> 其他

[相关活性小分子]

鲁米诺物理化学性质

[ 密度 ]:
1.4±0.1 g/cm3

[ 沸点 ]:
621.9ºC at 760 mmHg

[ 熔点 ]:
>300 °C(lit.)

[ 分子式 ]:
C₈H₇N₃O₂

[ 分子量 ]:
177.160

[ 闪点 ]:
329.9ºC

[ 精确质量 ]:
177.053833

[ PSA ]:
91.74000

[ LogP ]:
-0.71

[ 外观性状 ]:
黄色至绿色

[ 折射率 ]:
1.649

[ 储存条件 ]:
库房通风低温干燥

[ 稳定性 ]:
Stable. Combustible. Incompatible with strong oxidizing agents, strong acids, strong bases, strong reducing agents. Emits light on reaction with oxidizers.

[ 水溶解性 ]:
<0.1 g/100 mL at 19 ºC

鲁米诺MSDS

鲁米诺毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TH8890060

CHEMICAL NAME :: 1,4-Phthalazinedione, 5-amino-2,3-dihydro-

CAS REGISTRY NUMBER :: 521-31-3

LAST UPDATED :: 199709

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H7-N3-O2

MOLECULAR WEIGHT :: 177.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 500 umol/L

REFERENCE :: CHROAU Chromosoma. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1939- Volume(issue)/page/year: 99,360,1990 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7070 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)

鲁米诺安全信息

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xn:Harmful;

[ 风险声明 (欧洲) ]:
R22;R36/37/38

[ 安全声明 (欧洲) ]:
S26-S36/37-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
3

[ RTECS号 ]:
TH8890060

[ 海关编码 ]:
29339990

鲁米诺合成路线

鲁米诺上下游产品

鲁米诺上游产品

鲁米诺下游产品

鲁米诺制备

3-硝基苯二甲酸经环合，还原而得。将3-硝基苯二甲酸加入8%肼水溶液，加热使固体溶化。加乙二醇，在蒸发器内蒸去溶液中的过量水分，在215-220℃下加热2min，使杂环闭合，冷却后得黄色硝基化合物。冷却，加10%氢氧化钠溶液，搅拌，加入连二硫酸钠，加热至沸，保温5min，再加入乙酸，冷却得亮黄色产物。放置过夜，过滤得产物。

鲁米诺海关

[ 海关编码 ]: 2933990090

[ 中文概述 ]:
2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

鲁米诺文献

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In Arabidopsis thaliana, responses to pathogen-associated molecular patterns (PAMPs) are mediated by cell surface pattern recognition receptors (PRRs) and include the accumulation of reactive oxygen s...

H89 enhances the sensitivity of cancer cells to glyceryl trinitrate through a purinergic receptor-dependent pathway.

Oncotarget 6(9) , 6877-86, (2015)

High doses of the organic nitrate glyceryl trinitrate (GTN), a nitric oxide (NO) donor, are known to trigger apoptosis in human cancer cells. Here, we show that such a cytotoxic effect can be obtained...

Changing the paradigm for myoglobin: a novel link between lipids and myoglobin.

J. Appl. Physiol. 117(3) , 307-15, (2014)

Myoglobin (Mb) is an oxygen-binding muscular hemeprotein regulated via Ca(2+)-signaling pathways involving calcineurin (CN), with Mb increases attributed to hypoxia, exercise, and nitric oxide. Here, ...

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鲁米诺