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间氨基苯甲酸

间氨基苯甲酸用途

【用途一】
用作感光、医药中间体
【用途二】
医药和染料中间体。用于制造偶氮染料，医药乙碘苯酸和胆影酸，试剂。
【用途三】
检验铜。有机合成。制造偶氮染料。

间氨基苯甲酸名称

[ CAS 号 ]:
99-05-8

[ 中文名 ]:
间氨基苯甲酸

[ 英文名 ]:
3-Aminobenzoic acid

[中文别名 ]:

[英文别名 ]:

3-Aminobenzoic acid
Benzoic acid, m-amino-
Benzoic acid, 3-amino-
3-Aminobenzoesaeure
m-carboxyaniline
EINECS 202-724-4
m-aminobenzoic acid
MFCD00007795
m-Aminobenzoesaeure

间氨基苯甲酸物理化学性质

[ 密度 ]:
1.3±0.1 g/cm3

[ 沸点 ]:
352.5±25.0 °C at 760 mmHg

[ 熔点 ]:
178-180 °C(lit.)

[ 分子式 ]:
C₇H₇NO₂

[ 分子量 ]:
137.136

[ 闪点 ]:
167.0±23.2 °C

[ 精确质量 ]:
137.047684

[ PSA ]:
63.32000

[ LogP ]:
0.78

[ 外观性状 ]:
白色至黄褐色的晶体

[ 蒸汽压 ]:
0.0±0.8 mmHg at 25°C

[ 折射率 ]:
1.637

[ 储存条件 ]:
库房通风低温干燥

[ 水溶解性 ]:
5.9 g/L (15 ºC)

间氨基苯甲酸MSDS

间氨基苯甲酸毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG1225000

CHEMICAL NAME :: Benzoic acid, m-amino-

CAS REGISTRY NUMBER :: 99-05-8

BEILSTEIN REFERENCE NO. :: 0471603

LAST UPDATED :: 199710

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C7-H7-N-O2

MOLECULAR WEIGHT :: 137.15

WISWESSER LINE NOTATION :: ZR CVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 19,483,1946

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 6,53,1954

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 750 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

间氨基苯甲酸安全信息

[ 符号 ]:

GHS07

[ 信号词 ]:
Warning

[ 危害声明 ]:
H302-H315-H319-H335

[ 警示性声明 ]:
P261-P305 + P351 + P338

[ 个人防护装备 ]:
dust mask type N95 (US);Eyeshields;Gloves

[ 危害码 (欧洲) ]:
Xi:Irritant

[ 风险声明 (欧洲) ]:
R36/37/38

[ 安全声明 (欧洲) ]:
S26-S37/39

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
DG1225000

[ 海关编码 ]:
29224995

间氨基苯甲酸合成路线

间氨基苯甲酸上下游产品

间氨基苯甲酸上游产品

间氨基苯甲酸下游产品

间氨基苯甲酸制备

1、硝基苯甲酸催化加氢将间硝基苯甲酸溶于水中，加热至70℃以下，用10%液碱调节pH值，使pH值大于7。加入2%的活性炭，脱色20-30min，过滤。滤液以10%液碱调节pH8-8.5。向滤液中加入钯炭（即将2%氯化钯溶液缓缓加入水及活性炭的锅中，边加边搅拌，加完后再通氢气而得），加热至40-45℃，通氢至不再吸氢为止。滤去钯炭，得间氨基苯甲酸钠溶液。收率为95%。也可以用镍作催化剂，试验的结果，收率为99.8%；在1000ml烧杯中加入88%间硝基苯甲酸（按100%82.3g）、400ml水，用22%氢氧化钠调pH=6-7，待料液全溶后加入17g阮尼镍，在搅拌下把料液抽到摇摆式高压釜中，分别用氢气、氮气置换两次，再充压至3.92MPa，于压力2.94-3.92MPa、温度130-140℃下反应5h左右，氢压不下降为终点。经过滤、干燥而得成品。2.铁粉还原法在反应罐中加水、盐酸、氯化钠，升温到80℃。加入铁粉，95℃保温30min，分次投入间硝基苯甲酸，在100℃保温1h，冷却至80℃，用碳酸钠中和至pH9以上。于50℃时压滤，用水洗涤泥，得浅棕色还原液。用盐酸调节pH值，或用盐析的方法使间硝基苯甲酸析出，经过滤、干燥而得成品。收率90%。

间氨基苯甲酸海关

[ 海关编码 ]: 2922499990

[ 中文概述 ]:
2922499990 其他氨基酸及其酯及它们的盐（含有一种以上含氧基的除外）. 增值税率:17.0% 退税率:9.0% 监管条件:AB(入境货物通关单,出境货物通关单) 最惠国关税:6.5% 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途, 乙醇胺及其盐应报明色度, 乙醇胺及其盐应报明包装

[ 监管条件 ]: A.入境货物通关单 B.出境货物通关单

[ 检验检疫 ]: P.进境动植物、动植物产品检疫 Q.出境动植物、动植物产品检疫 R.进口食品卫生监督检验 S.出口食品卫生监督检验 M.进口商品检验 N.出口商品检验

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

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