环香豆素
环香豆素用途
环香豆素名称
[ CAS 号 ]:
518-20-7
[ 中文名 ]:
环香豆素
[ 英文名 ]:
pyranocoumarin
[中文别名 ]:
[英文别名 ]:
- Pyranocumarin [German]
- Cumopyran
- Compound 63 link
- CYCLOCUMAROL
- Methanopyranorin
- Cyclocoumarol
- Anticoagulans 63
- BL 5
- Cumopyrin
- Pyranocoumarin
环香豆素物理化学性质
[ 密度 ]:
1.27g/cm3
[ 沸点 ]:
488.6ºC at 760 mmHg
[ 熔点 ]:
166°
[ 分子式 ]:
C20H18O4
[ 分子量 ]:
322.35500
[ 闪点 ]:
216.2ºC
[ 精确质量 ]:
322.12100
[ PSA ]:
48.67000
[ LogP ]:
4.07000
[ 折射率 ]:
1.624
环香豆素毒性和生态
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ0335200
- CHEMICAL NAME :
- 2H,5H-Pyrano(3,2-c)(1)benzopyran-5-one, 3,4-dihydro-2-methoxy-2-methyl-4-phenyl-
- CAS REGISTRY NUMBER :
- 518-20-7
- LAST UPDATED :
- 199409
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H18-O4
- MOLECULAR WEIGHT :
- 322.38
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,142,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A355,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 83,471,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 83,471,1953
环香豆素安全信息
[ 符号 ]:
GHS06
[ 信号词 ]:
Danger
[ 危害声明 ]:
H310
[ 警示性声明 ]:
P262-P280-P302 + P352 + P310-P361 + P364
[ 个人防护装备 ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ 危害码 (欧洲) ]:
T+
[ 风险声明 (欧洲) ]:
27
[ 安全声明 (欧洲) ]:
28-36/37-45
[ 危险品运输编码 ]:
UN 2811
[ RTECS号 ]:
UQ0335200
[ 包装等级 ]:
III
[ 危险类别 ]:
6.1(b)
[ 海关编码 ]:
2932999099
环香豆素海关
[ 海关编码 ]: 2932999099
[ 中文概述 ]:
2932999099. 其他仅含氧杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
[ 申报要素 ]: 品名, 成分含量, 用途
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
环香豆素文献
J. Med. Chem. 27(8) , 1092-5, (1984)
An octanol/water model system and circular dichroism (CD) spectroscopy have been used to study the solution conformation of warfarin in aqueous and lipid environments. Upon partitioning of (S)-warfari...
Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.Arch. Biochem. Biophys. 372(1) , 16-28, (1999)
Possible reasons for the observed differences in metabolic behavior and drug interaction liability between the structurally similar oral anticoagulants warfarin and phenprocoumon were explored. Incuba...
Inhibitory effect of coumarins on HIV-1 replication and cell-mediated or cell-free viral transmission.Acta Virol. 37(4) , 241-50, (1993)
A single dose of coumarin derivatives, warfarin, 4-hydroxycoumarin and umbelliferone, added at the time of inoculation either by free virus or by contact with U1 monocytes exhibited a dose-dependent i...
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推荐生产厂家/供应商:
公司名:上海阿拉丁生化科技股份有限公司
区域:上海市浦东新区
价格:
¥1354.0/100mg
¥需询单/1g
¥需询单/1g
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联系人:阿拉丁李高志
产品详情:吡喃香豆素
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相关化合物
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