香紫苏醇

香紫苏醇用途

Sclareol 从 Salvia sclarea 中分离出来,具有抗癌活性。 Sclareol 对小鼠白血病 (P-388),人表皮癌 (KB),以及人白血细胞具有很强的细胞毒活性。Sclareol 诱导细胞凋亡( apoptosis)。

香紫苏醇名称

[ CAS 号 ]:
515-03-7

[ 中文名 ]:
香紫苏醇

[ 英文名 ]:
Sclareol

[中文别名 ]:

[英文别名 ]:

SCLAREOL(RG)
EINECS 208-194-0
Labd-14-ene-8,13-diol, (13R)-
SCIADONIC ACID
labd-14-ene-8,13(R)-diol
MFCD00869558
SCLAREOL,NATURAL
SCAREOL
Sclareol
(-)-sclareol

香紫苏醇生物活性

[ 描述 ]:

[ 相关类别 ]:

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

[体外研究]

Sclareol对14株人白血病细胞系中的13株具有细胞毒性,IC50值在6.0-24.2μg/mL之间,但对相同剂量范围内的外周血单核白细胞无细胞毒性[1]。

[参考文献]

[1]. Robert Tisserand, et al. Sclareol.Constituent profiles

香紫苏醇物理化学性质

[ 密度 ]:
1.0±0.1 g/cm3

[ 沸点 ]:
398.3±15.0 °C at 760 mmHg

[ 熔点 ]:
95-100 °C(lit.)

[ 分子式 ]:
C₂₀H₃₆O₂

[ 分子量 ]:
308.499

[ 闪点 ]:
169.1±15.0 °C

[ 精确质量 ]:
308.271515

[ PSA ]:
40.46000

[ LogP ]:
5.54

[ 外观性状 ]:
白色细粉末

[ 蒸汽压 ]:
0.0±2.1 mmHg at 25°C

[ 折射率 ]:
1.490

[ 储存条件 ]:
2-8C

[ 水溶解性 ]:
水溶性：不溶

香紫苏醇MSDS

香紫苏醇毒性和生态

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QK0301900

CHEMICAL NAME :: 1-Naphthalenepropanol, decahydro-alpha-ethenyl-2-hydroxy-alpha,2,5,5,8a-pent amethyl-, (1R-(1-alpha(R*),2-beta,4a-beta,8a-alpha))-

CAS REGISTRY NUMBER :: 515-03-7

BEILSTEIN REFERENCE NO. :: 2054148

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C20-H36-O2

MOLECULAR WEIGHT :: 308.56

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,115S,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 30,115S,1992

香紫苏醇安全信息

[ 个人防护装备 ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ 危险品运输编码 ]:
NONH for all modes of transport

[ WGK德国 ]:
2

[ RTECS号 ]:
QK0301900

[ 海关编码 ]:
2906199090

香紫苏醇合成路线

香紫苏醇上下游产品

香紫苏醇上游产品

香紫苏醇下游产品

香紫苏醇制备

1. 香紫苏醇是从香紫苏(Salvia Sclarea L.)水蒸气提油后的残渣用溶剂萃取得到。或者香紫苏植物用溶剂萃取，经水蒸气蒸馏，将香紫苏挥发油分去后，残留物脱蜡、重结晶即可得到产品(溶剂有：石油醚、三氯乙烯等；混合溶剂有甲醇或乙醇或乙二醇的石油醚溶液)。

2. 烟草：9。

香紫苏醇海关

[ 海关编码 ]: 2906199090

[ 中文概述 ]:
2906199090. 其他环烷醇，环烯醇及环萜烯醇. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:5.5%. 普通关税:30.0%

[ 申报要素 ]: 品名, 成分含量, 用途

[ Summary ]:
2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

香紫苏醇文献

Parallel dual secondary column-dual detection: a further way of enhancing the informative potential of two-dimensional comprehensive gas chromatography.

J. Chromatogr. A. 1360 , 264-74, (2014)

Comprehensive two-dimensional gas chromatography (GC×GC) coupled with Mass Spectrometry (MS) is one of today's most powerful analytical platforms for detailed analysis of medium-to-high complexity sam...

Labdane diterpenoids from Salvia reuterana.

Phytochemistry 108 , 264-9, (2014)

Three labdane diterpenoids, 14α-hydroxy-15-chlorosclareol (1), 14α-hydroxy-15-acetoxysclareol (2), and 6β-hydroxy-14α-epoxysclareol (3), together with the known diterpenoids sclareol (4), 6β-hydroxysc...

Isolation, chemical, and biotransformation routes of labdane-type diterpenes.

Chem. Rev. 111(8) , 4418-52, (2011)

更多文献